Tracking the brain dynamics of gut hormone influences on food image discrimination in normal-weight women across hunger states
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1
CHUV Lausanne, Switzerland
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2
UNI Lausanne, Switzerland
Endocrine factors convey information about energy needs to brain regions involved in the homeostatic control of feeding. Likewise, both the control of food intake and viewing of foods (independent of their ingestion) also address brain areas implicated in reward evaluation and decision-making. The extent to which low-level endocrine factors interact with higher-level cognitive processes and brain areas involved therein is still unknown. We concurrently recorded endocrine factors and visual evoked potentials (VEPs) during food and non-food image viewing in women following an overnight fast and in post-prandial state. Global VEP differences as a function of nutrition state surfaced from 130ms post-image onset. In a hungry state, VEPs to foods vs. non-foods differed substantially earlier (~130ms) than in post-prandial state (~195ms). Neural source estimations identified differences between the responses to food and non-food stimuli in a wide network of brain regions typically associated with food object processing, food motivation and also decision-making. In particular, neural activity in regions showing reliably higher responses to food viewing was found to vary by nutrition state. The modulations in neural source activity during food viewing correlated negatively with insulin blood levels in fasted state, i.e. with a digestive hormone usually released only after food intake. On the other hand, positive correlations were observed with blood-level concentrations of ghrelin and the pancreatic peptide YY in post-prandial state, i.e. with hormones regulating food intake motivation. These findings reveal interactions of nutrition state and the gut-brain axis that are central to understanding deviant eating behaviors leading and for developing intervention strategies.
Keywords:
Perception,
VEPs
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Neurophysiology of Sensation and Perception
Citation:
Lietti
CV,
Saugy
J,
Egli
L,
Campos
V,
Tappy
L,
Giusti
V,
Murray
MM and
Toepel
U
(2011). Tracking the brain dynamics of gut hormone influences on food image discrimination in normal-weight women across hunger states.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00347
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Received:
23 Nov 2011;
Published Online:
28 Nov 2011.
*
Correspondence:
Dr. Claudia V Lietti, CHUV Lausanne, Lausanne, Switzerland, claudia.lietti@chuv.ch