Cortical representation of high-frequency oscillations in Landau-Kleffner syndrome revealed by magnetic source imaging
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1
Erasmus Hospital, Belgium
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2
Reference Center for Refractory Epilepsy, Ghent University Hospital., Belgium
Purpose: High-frequency oscillations (HFOs, 90-140 Hz) concurrent with spike-wave discharges (SWDs) have been recently described in epileptic encephalopathy with continuous spike-waves during slow sleep (CSWS) using scalp electroencephalography (Kobayashi et al., Epilepsia 2010;51:2190-2194). Here, we investigate the neuronal correlate of HFOs in 3 patients with Landau-Kleffner syndrome (LKS) using magnetic source imaging.
Method: 3 children (2 boys, aged 4.5 to 8 years) with LKS underwent whole-head magnetoencephalography (MEG) recordings (band-pass: 0.1–330 Hz, sampling rate: 1 kHz; Vectorview, Elekta) under sedation. For each patient, SWDs typical of CSWS were selected. HFOs were indentified using individuals’ SWDs spectrograms averaged with respect to SWDs peak power. SWDs cortical sources were identified using dynamic statistical parametric mapping. HFO’s were localized using beamforming technique.
Results: SWDs epileptogenic sources were located at the right supra-temporal auditory cortex (AC) in two patients and at the left AC in one patient. In all patients, SWDs rapidly propagated to the opposite AC. Spectrograms identified HFOs during SWDs in the 120-140 Hz range on temporal MEG sensors ipsilateral to epileptogenic sources for 2 patients and on both side for 1 patient. HFOs neuronal sources co-localized with SWDs epileptogenic sources and reached maximum power on average 20 milliseconds after SWDs onset.
Conclusion: This study confirms the existence of HFOs in CSWS syndromes and demonstrates a common neuronal generator for HFOs and SWDs epileptogenic sources in LKS. HFOs are not involved in the generation of the epileptic activity.
Keywords:
Epilepsy,
Landau-Kleffner Syndrome,
Magnetoencephalography,
HFOs,
Spike-wave discharge
Conference:
Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Other basic/clinical neurosciences topic
Citation:
Op De Beeck
M,
Bourguignon
M,
Carrette
E,
Boon
P,
Goldman
S,
Van Bogaert
P and
De Tiège
X
(2012). Cortical representation of high-frequency oscillations in Landau-Kleffner syndrome revealed by magnetic source imaging.
Conference Abstract:
Belgian Brain Council.
doi: 10.3389/conf.fnhum.2012.210.00018
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Received:
10 Sep 2012;
Published Online:
12 Sep 2012.
*
Correspondence:
Mr. Marc Op De Beeck, Erasmus Hospital, Brussels, Belgium, maopdebe@ulb.ac.be