Heterotopic noxious analgesia (DNIC) in migraine patients during and between attacks: an fMRI study.
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1
ULg, Neurology & GIGA Neurosciences, Belgium
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2
University of Liège, Coma Science Group, Belgium
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3
Université d'Auvergne, U929. Neurobiologie de la douleur trigéminale et céphalique, France
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4
University of Liège, Cyclotron Research Center, Belgium
Background
Diffuse noxious inhibitory controls (DNIC), or heterotopic noxious analgesia, engage prefrontal cortical areas as well as brain stem centers (Piché et al. 2009), both of which may be dysfunctioning in migraine (Goadsby et al. 2009).
Objectives
To search with fMRI for abnormalities in prefrontal cortex and brain stem activation during DNIC in migraine.
Methods
Blood oxygenation level dependent (BOLD) responses to laser heat stimuli on the left hand were recorded with and without continuous noxious cold applied on the right foot. We studied migraineurs between (n=14) and during attacks (n=5) and compared the results to those obtained previously in healthy volunteers (n=24)
Results
In the left dorsal pons the reduction of the laser-induced BOLD response by heterotopic noxious cold was significantly greater during ictal recordings than interictally or than in healthy volunteers. Moreover, the BOLD response in the premotor cortex induced by either cold or warm application on the foot was significantly increased in migraine patients during an attack.
Conclusion
In a pontine area close to that known to be activated during migraine attacks (Goadsby et al. 2009) we found ictally increased DNIC activation. This may suggest that this brain stem area is engaged in pain control and thus secondarily activated during the attack. The increased activation to the foot stimuli in premotor cortex could reflect ictal allodynia and/or increased motor control to avoid movement in the scanner.
References
Piche M, Arsenault M, Rainville P Cerebral and cerebrospinal processes underlying counterirritation analgesia. J Neurosci. 2009; 29: 14236-14246.
Goadsby PJ, Charbit AR, Andreou AP, Akerman S, Holland PR. Neurobiology of migraine. Neuroscience. 2009;161(2):327-41.
Keywords:
DNIC,
heterotopic noxious analgesia,
Migraine,
fMRI BOLD,
ictal,
interictal
Conference:
Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Other basic/clinical neurosciences topic
Citation:
Viganò
A,
Bogdanov
V,
Noirhomme
Q,
Dallel
R,
Guy
N,
Laureys
S,
Phillips
C and
Schoenen
J
(2012). Heterotopic noxious analgesia (DNIC) in migraine patients during and between attacks: an fMRI study..
Conference Abstract:
Belgian Brain Council.
doi: 10.3389/conf.fnhum.2012.210.00120
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Received:
10 Aug 2012;
Published Online:
12 Sep 2012.
*
Correspondence:
Prof. Jean Schoenen, ULg, Neurology & GIGA Neurosciences, LIEGE, 4000, Belgium, jschoenen@ulg.ac.be