New vistas on system level consolidation in humans
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1
Radboud University, Donders Institute for Brain, Cognition, and Behaviour, Netherlands
Hippocampal lesions cause temporally graded retrograde amnesia, suggesting a time-limited role of the hippocampus. This phenomenon forms the basis of the standard model of system-level consolidation, which proposes that the hippocampus is part of a retrieval network for recent memories, but that memories are gradually more dependent on neocortical circuits alone. Here I will present a series of studies probing system-level consolidation, which is characterized by changes in network properties and local activity. We used standard approaches like psychophysiological interaction probing neural consequences of consolidation at retrieval. However, such approaches are insufficient to probe neural correlates of consolidation directly, because its time course is unknown. Therefore, we used either model-free methods like interregional partial correlations to probe functional connectivity during a rest period following encoding or we investigated responses to memory-related cues during sleep. To vary consolidation experimentally, we contrasted recent and remote memories in some experiments and slow and fast consolidation in others. We manipulated the speed of consolidation by manipulating the degree by which new information can be assimilated into existing mental schemata. These behavioral paradigms combined with adequate connectivity analyses appear to provide the instrumentation to study the neural underpinnings of how we retain new information for long-term use.
Keywords:
Memory,
consolidation,
HIPPOCAMPUS AND MEMORY,
fMRI,
network,
Schemas
Conference:
Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012.
Presentation Type:
Oral Presentation (only for invited speakers)
Topic:
Higher Brain Functions in health and disease: cognition and memory
Citation:
Fernandez
G
(2012). New vistas on system level consolidation in humans.
Conference Abstract:
Belgian Brain Council.
doi: 10.3389/conf.fnhum.2012.210.00128
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Received:
06 Aug 2012;
Published Online:
12 Sep 2012.
*
Correspondence:
Prof. Guillen Fernandez, Radboud University, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, Netherlands, g.fernandez@donders.ru.nl