Antidepressant Effect of Barley Grains Incompare with Prozac Drug : Biochemical and Cytological Studies on Skeletal Muscles of Mice .
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Assistant Professor - Histology & Cell Biology - in college of Science ,Alexandria University ,Egypt., Egypt
Problem Statement : The dysfunction of serotonin, norepinephrine and/or dopamine systems might contribute to depression. Many antidepressant drugs work by modulating these neurotransmission systems as Prozac drug but with adverse effects. The purpose of this study was comparing between the antidepressant effect of Barley grains with antidepressant drug (Prozac) on skeletal muscle of depressed mouse model ,as Barley had been referred in arabian traditional medicine for the treatment of depression.
Approach: Forty adult mice assigned into four groups : –ve control ( normal social environment) , + ve control (socially isolated), Prozac (socially isolated) received an intraperitoneal injection (0.06 mg. Prozac / mouse / day-1 ) and Barley (socially isolation) supplemented with Barley grains instead the usual food (5 g .Barley / mouse /day-1 ) for 30 days. A comparative observations included biochemical and cytological changes were recorded.
Results: In +ve control-group exhibited hyperglycemia ,had peripheral nerve with small accessory ending, short sarcomeres, accumulation of huge mitochondria, nerve terminals devoided of mitochondria but with electron-dense synaptic vesicles. Barley –group exhibited hypoglycemia, low concentrations of lactate dehydrogenase, had side motor nerve trunk and neuromuscular junction demonstrating normative appearance. In the other hand, Prozac- group attained the maximum level of creatinine kinase and total cholesterol, lower level of creatinine ,had degenerated axon terminal which failed to reach the subneural apparatus, myofillaments autolysis, incidence of mitochondrial cristolysis , diminished neuromuscular junction and demyelinated peripheral axons.
Conclusions/Recommendations: From the results obtained in this work, it was concluded that Barley reduce risk factors and might be therapeutic in preventing or treating many psychiatric and emotional disorders leading to more healthy life.
Keywords:
Prozac Drug,
Barley Grains,
biochemical,
cytology,
skeletal muscles,
Neuromuscular Junction,
peripheral axon.
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Ali
AM
(2013). Antidepressant Effect of Barley Grains Incompare with Prozac Drug : Biochemical and Cytological Studies on Skeletal Muscles of Mice ..
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00004
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Received:
28 Mar 2013;
Published Online:
11 Apr 2013.
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Correspondence:
Dr. Awatef M Ali, Assistant Professor - Histology & Cell Biology - in college of Science ,Alexandria University ,Egypt., Alexandria, Egypt, Awatef-Ali@hotmail.com