Ameliorative effect of dexmedetomidine and its combination with tramadol or amitriptyline in rat model of neuropathic pain
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1
Department of Pharmacology, Faculty of medicine., Pharmacology, Egypt
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2
Zoology Department, Faculty of Science, Alexandria University, Egypt
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3
South Egypt Cancer Institute, Assiut University , faculty of Medicine, Egypt
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4
Department of Anaesthesia, Faculty of Medicine, Assiut University, Egypt, Egypt
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5
Department of Neurology, Faculty of Medicine, Assiut University Hospital, Faculty of medicine, Neurology, Egypt
Interactions between sympathetic and somatic nervous system play an essential role in the pathophysiologic mechanisms of neuropathic pain. The aim of the present study was to investigate the possible antinociceptive effect of dexmedetomidine, an α2-adrenoceptor agonist, and its combination with front-line treatment of neuropathic pain i.e. amitriptyline or tramadol in chronic constriction injury (CCI) model of sciatic nerve in rats. The effect of intraperitoneal (i.p.) dexmedetomidine (5μg/kg), tramadol (5 mg/kg) and amitriptyline (30 mg/kg) on mechanical allodynia (measured by electrical von Frey apparatus) and hyperalgesia (measured by Randall and Selitto test) was studied after CCI. The sham-operated rats and un-operated hind paw (right paw) press normally on the floor reproduced by a weighted pain score of 0. Behavioral and mechanical tests, confirmed the development of neuropathic pain after CCI. Dexmedetomidine, amitriptyline, tramadol, amitriptyline + dexmedetomidine and tramadol + dexmedetomidine combination did not produce any sedation/motor impairment (p>0.05). The combination of these drugs is more effective in increasing the pain threshold after peripheral nerve injury, when compared with the administration of either of amitriptyline or tramadol alone at several time points.
Keywords:
neuropathic pain,
Amitriptyline,
Dexmedetomidine,
rat,
Tramadol
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Farghaly
H,
Abd-ellatief
R,
MOFTAH
MZ,
Galal
M,
Kotb
H and
Khedr
EM
(2013). Ameliorative effect of dexmedetomidine and its combination with tramadol or amitriptyline in rat model of neuropathic pain.
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00030
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Received:
29 Mar 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Prof. Eman M Khedr, Department of Neurology, Faculty of Medicine, Assiut University Hospital, Faculty of medicine, Neurology, Assiut city, Egypt, emankhedr99@yahoo.com