Set-switching in obsessive-compulsive disorder: An ERP comparison with panic disorder.
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1
University of Wollongong, Graduate School of Medicine, Australia
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2
Brain & Behaviour Research Institute, University of Wollongong, Australia
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3
School of Psychology, University of Wollongong, Australia
Aims: Cognitive flexibility, including the ability to shift adaptively between changing tasks or rules, may be impaired in obsessive-compulsive disorder (OCD), contributing to repetitive symptoms. Brain mechanisms and the specificity of set-shifting difficulties to OCD are inadequately understood. We investigated the neurophysiology of set-shifting in participants with OCD versus healthy and anxious controls. Method: Participants with OCD (n= 20) versus healthy (n= 20) and anxious controls with panic disorder (n= 20) performed a specially designed Go/ NoGo task, where some stimuli had switching, and some had fixed, response requirements. ERPs, response time (RT) and accuracy were compared between groups. Results: Switch costs occurred in terms of higher errors to switching stimuli across participant groups, particularly commission errors to switching NoGo stimuli. For N2, there was a Switch by Go/ NoGo interaction, with the largest N2 amplitude occurring to switching NoGo stimuli. Additionally, N2 latency was longer to switching stimuli. Classic NoGo enlargement and anteriorisation occurred for N2-P3, across groups. Both clinical groups had higher switching versus non-switching P3 amplitude, compared to healthy controls. Additionally, clinical groups shared general RT impairments and atypical topography of N2. Conclusions: We identified similar general deficits and ERP anomalies during task-switching in OCD and panic disorder, precluding OCD-specific interpretations. Both conditions may be characterised by shared anomalies in cognitive flexibility and control.
Keywords:
set-shifting,
OCD,
inhibition,
ERPs,
Panic Disorder,
P3,
N2
Conference:
ASP2013 - 23rd Annual meeting of the Australasian Society for Psychophysiology, Wollongong, Australia, 20 Nov - 22 Nov, 2013.
Presentation Type:
Oral Presentation
Topic:
Cognitive control
Citation:
Thomas
SJ,
Gonsalvez
CJ and
Johnstone
SJ
(2013). Set-switching in obsessive-compulsive disorder: An ERP comparison with panic disorder..
Conference Abstract:
ASP2013 - 23rd Annual meeting of the Australasian Society for Psychophysiology.
doi: 10.3389/conf.fnhum.2013.213.00016
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Received:
05 Nov 2013;
Published Online:
05 Nov 2013.
*
Correspondence:
Dr. Susan J Thomas, University of Wollongong, Graduate School of Medicine, Wollongong, NSW, Australia, sthomas@uow.edu.au