Sleep slow-wave activity predicts changes in human cortical excitability during extended wakefulness
Giulia
Gaggioni1*,
Julien
Q.
Ly1*,
Dorothée
Coppieters 'T Wallant1,
Vincenzo
Muto1,
Chloé
Borsu1,
Soterios
N.
Papachilleos1,
Alexandre
Brzozowski1,
Simone
Sarrasso2,
Mario
Rosanova2,
Simon
N.
Archer3,
Pierre
Maquet1,
Derk-Jan
Dijk3,
Christophe
Phillips1,
Marcello
Massimini2,
Gilles
Vandewalle1 and
Sarah
L.
Chellappa1
-
1
Cyclotron Research Centre, Belgium
-
2
Department of Clinical Sciences Luigi Sacco, Università degli Studi di Milano, Italy
-
3
Surrey Sleep Research Centre, University of Surrey, United Kingdom
Objective. Slow-wave activity (SWA: 0.75-4.0 Hz) is a classical hallmark of sleep homeostasis. It is associated to synaptic downscaling, leading to a gradual decrease of cortical excitability during sleep. Here we investigated whether SWA predicts subsequent human cortical excitability during extended wakefulness.
Methods. After 8h nocturnal sleep, 19 healthy young men (18-30y) followed a 28h sleep deprivation protocol under constant routine conditions, during which they underwent 8 EEG recordings of transcranial magnetic stimulation (TMS)-evoked potentials. Sleep was scored using AASM criteria, and power spectra were calculated. Cortical excitability was inferred from the amplitude of the first component of TMS-evoked potentials over prefrontal cortex. A linear regression between frontal SWA (upper asymptote during first NREM sleep cycle) and cortical excitability was computed.
Results. Analyses reveal a significant positive regression between first NREM cycle SWA and cortical excitability assessed after 24h of continuous wakefulness, during the so-called “sleep-promoting zone”, i.e. when the circadian system maximally promotes sleep (r>.27; p<.03). Interestingly, first NREM cycle SWA significantly and positively regresses with the overnight variation of cortical excitability, i.e. the change observed from the evening wake-maintenance to the morning sleep-promoting zones (r=.23; p=.05).
Conclusions. Our data show that sleep SWA is tied to the subsequent build-up of cortical excitability during prolonged wakefulness, particularly during critical time windows for the interplay of circadian and sleep homeostasis processes. We speculate that this build-up of cortical excitability during wakefulness increases subsequent SWA during sleep, through a mutual interaction.
Acknowledgements
Fundings:WBI-AXA-FNRS-Ulg-FMRE-ARC.
Keywords:
slow-wave activity,
cortical excitability,
EEG-TMS,
Polysomnography,
Sleep Deprivation,
SWA,
NREM
Conference:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014.
Presentation Type:
Poster Presentation
Topic:
Basic Neuroscience
Citation:
Gaggioni
G,
Ly
JQ,
Coppieters 'T Wallant
D,
Muto
V,
Borsu
C,
Papachilleos
SN,
Brzozowski
A,
Sarrasso
S,
Rosanova
M,
Archer
SN,
Maquet
P,
Dijk
D,
Phillips
C,
Massimini
M,
Vandewalle
G and
Chellappa
SL
(2014). Sleep slow-wave activity predicts changes in human cortical excitability during extended wakefulness.
Conference Abstract:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
doi: 10.3389/conf.fnhum.2014.214.00038
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Received:
30 Jun 2014;
Published Online:
30 Jun 2014.
*
Correspondence:
Ms. Giulia Gaggioni, Cyclotron Research Centre, Liège, Belgium, giulia.gaggioni@doct.ulg.ac.be
Mr. Julien Q Ly, Cyclotron Research Centre, Liège, Belgium, julienlycrc@gmail.com