State-dependent high frequency power changes in human neonatal EEG
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1
University of California, Berkeley, Helen Wills Neuroscience Institute, United States
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2
Children's Hospital and Research Center, Neurology, United States
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3
University of California, Berkeley, Psychology, United States
High frequency oscillatory brain signals (high gamma; HG: 70-200 Hz) reliably track numerous cognitive abilities including language, movement, perception, memory and executive control. Critically, HG activity typically cannot be measured in scalp EEG due to the 1/f power law and signal attenuation by the skull. Thus, in humans these brain signals are usually studied using invasive surgical techniques such as electrocorticography (ECoG) involving subdural or intracerebral electrodes. The skull is much thinner in human neonates than in adults, and in certain areas, known as fontanelles, the skull has not yet fused. Because of this and evidence that we could record HG from patients with a hemicraniotomy, we hypothesized that high frequencies not typically seen in adult scalp EEG may be detectable in neonates. High frequency EEG (1000 Hz sampling rate) was continuously recorded from healthy neonates (n=14; 1-4 months) undergoing outpatient EEG for a possible seizure. All neonates were developmentally normal and had no evidence of epileptic activity in their EEGs. High gamma power (75 - 200 Hz) was extracted from data acquired during both sleep and awake periods. We found enhanced high gamma power when the infants were awake compared to when asleep (p<0.05). Additionally, we observed increased beta-high gamma phase-amplitude coupling in the awake periods compared with sleep (p<0.05). The results provide evidence that high frequency activity can be recorded from the scalp of neonates opening up a potential metric for developmental studies in health and disease.
Keywords:
EEG,
oscillations,
Cross-frequency coupling,
high gamma,
neonates
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Cano
M,
Kuperman
R,
Anderson
K and
Knight
R
(2015). State-dependent high frequency power changes in human neonatal EEG.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00069
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Ms. Maya Cano, University of California, Berkeley, Helen Wills Neuroscience Institute, Berkeley, United States, mcano@berkeley.edu