Cognitive development and volumes of the corpus callosum and lateral ventricles in normal and premature infants
-
1
Institute of Neurobiology, National Autonomous University of Mexico, Behavioral and Cognitive Neurobiology, Mexico
-
2
Neuroscience Center, Neuroinformatics, Cuba
Despite advances in medicine, the incidence of births at-risk for brain damage has not diminished. Prematurity is a major contributor to perinatal morbidity and mortality around the world. Even in those preterm infants who survive without apparent motor disability, there is substantial reduction in mean IQ and more frequent cognitive and educational difficulties. For this reason we conduct a multidisciplinary longitudinal approach to study neonates with history of risk factors for brain damage. Methods: Two groups of 180 MRI from healthy infants and 153 MRI from preterm infants between 1 month and 3 years. Sparse regression classifiers using General Linear Model via Elastic Net, combined with stable based Receive Operating Curves analysis, were applied to the volumes of the corpus callosum (CC) and from left and right lateral ventricles. Results: The ROC analysis showed that, at the age of 6 months there was a 97% of classification between the two groups (85% for a level of 10% of False Positives). The classification power of each variable separately was lower than the combination of the three. Separately the CC had a significantly higher classification power than the lateral ventricles. At 6 months the volumes of the CC had a significant correlation with Bayley’s cognitive scores (r=0.34, p=0.02) and at 12 months, had a significant correlation with cognitive (r=0.44, p=0.002) and motor scores (r=0.32, p=0.037). Small volumes of the CC were related with low cognitive and motor scores. Conclusions: thinning of the CC is often found in cerebral palsy, and as the genu section connects both prefrontal and orbito-frontal regions, genu atrophy may explain the cognitive deficiencies observed in those children with history of risk factors for brain damage. Acknowledgements.- This project was partially supported by Grant I0017 Fondo SEP - CONACYT 166772 and PAPIIT IN204613. The authors acknowledge Héctor Belmont, Juan José Ortiz Retana for their technical participation.
Keywords:
Corpus Callosum,
neurodevelopment,
infants,
preterm,
Bayley
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Harmony
T,
Cruz
Y,
Bosch-Bayard
J,
Cruz
E,
Hinojosa
M,
Fernandez
T,
Ricardo-Garcell
J and
González-Frankenberger
B
(2015). Cognitive development and volumes of the corpus callosum and lateral ventricles in normal and premature infants.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00137
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Prof. Thalía Harmony, Institute of Neurobiology, National Autonomous University of Mexico, Behavioral and Cognitive Neurobiology, Queretaro, Mexico, thaliaharmony79@gmail.com