Mapping development of the MMN and P3a potentials during adolescence: A longitudinal investigation of healthy individuals and individuals at-risk for psychosis
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1
University of New South Wales, School of Psychiatry, Australia
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2
Schizophrenia Research Institute, Australia
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3
Insitute of Psychiatry, King's College London, Department of Forensic & Neurodevelopmental Sciences, UK
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4
Institute of Psychiatry, King's College London, Department of Forensic & Neurodevelopmental Sciences, UK
Adolescence marks a period of transition from childhood to adulthood that is characterised by major changes in brain structure and function, and increased vulnerability to psychiatric disorder, including psychosis. Characterising normative developmental trajectories of brain function establishes an important baseline against which to map mechanisms contributing to pathological development. Cross-sectional investigations measuring the mismatch negativity (MMN) and P3a event-related potential components in healthy children and young adults have typically inferred increasing amplitudes and decreasing latencies during adolescence, interpreted as improved efficiency of sensory and cognitive processing. We sought to characterise within-individual trajectories of brain function in adolescence using a longitudinal design incorporating up to three assessments from late childhood though adolescence. Using a duration deviant passive auditory oddball paradigm, MMN and P3a components were recorded from 49 healthy children at approximately 24-month intervals (spanning ages 9-17 years). Linear mixed models, accounting for repeated measures, examined MMN and P3a amplitude and latency data from electrode FCz. Children at early pubertal stages had smaller MMN amplitude than adolescents in later pubertal stages, whereas MMN latency did not change with age or pubertal status. Random intercept models revealed a significant linear increase in P3a amplitude with age, while P3a latency increased initially from 11 years and stabilised by around 15 years. Longitudinal data analysis in children at-risk for psychosis is being finalised, with the aim of identifying the age(s) at which developmental trajectories of these components begin to diverge from the norm, and the nature of these deviations (e.g., delay vs. arrest of development).
Keywords:
Attention,
psychosis,
ERP,
developmental psychopathology,
child and adolescent development
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Attention
Citation:
Laurens
K,
Murphy
J,
Dickson
H and
Roberts
R
(2015). Mapping development of the MMN and P3a potentials during adolescence: A longitudinal investigation of healthy individuals and individuals at-risk for psychosis.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00267
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Dr. Kristin Laurens, University of New South Wales, School of Psychiatry, Sydney, Australia, Kristin.Laurens@unsw.edu.au