The rich club of the brain in bipolar disorder
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1
Leibniz Institute for Neurobiology, Clinical Affective Neurology Laboratory, Germany
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2
QIMR Berghofer Medical Research Institute, Systems Neuroscience, Australia
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3
University of New South Wales, Australia
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4
Black Dog Institute, Australia
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5
QIMR Berghofer Medical Research Institute, Australia
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6
University of New South Wales, School of Psychiatry, Australia
Introduction:
The human connectome is organised around a backbone of interconnected hubs called the rich club. Many rich club regions are involved in mood, salience and intero-ception, including the anterior cingulate, insula and dorsolateral prefrontal cortex: We hence sought to study the rich club in subjects with bipolar disorder and those at genetic risk of the same.
Methods:
Imaging data were acquired from 46 subjects with bipolar disorder, 61 first degree relatives and 69 matched controls. Structural connectivity was reconstructed from diffusion weighted images using probabilistic tractography. Data was parcellated into the Automated Annotated Atlas, then further partitioned into 500 regions covering cortical and subcortical grey matter.
Results:
1. Rich club coefficient:
We studied how strongly interconnected the hubs were by analyzing the rich club coefficient. For this analysis, connectivity data were first thresholded at a sparse density and binarised: These results hence speak to the total number of strong connections between nodes. The rich club was identified by iteratively removing nodes with few connections and calculating the number of remaining connections between hubs. First degree bipolar relatives have a significantly enriched rich club across a broad range of node degree (p<0.026, FWE corrected).
2. Global influence:
We defined the most consistent rich club, feeder and satellite nodes across all subjects. The rich club includes regions in the dorsolateral prefrontal cortex, inferior frontal gyrus and the anterior insula. Notably there was a significant reduction in mean strength between bipolar and healthy subjects (p<0.0162).
Discussion:
Our analyses suggest that an enriched internal connectivity of rich club nodes in participants at risk of bipolar disorder. This occurs in the absence of differences in the total connectivity of these regions, suggesting a specific internal reorganization between the rich hubs in those at risk of bipolar disorder.
Keywords:
MRI,
bipolar,
graph theory,
Diffusion Weighted Imaging,
rich club
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Methods Development
Citation:
Lord
A,
Roberts
G,
Breakspear
M and
Mitchell
P
(2015). The rich club of the brain in bipolar disorder.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00272
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Mr. Anton Lord, Leibniz Institute for Neurobiology, Clinical Affective Neurology Laboratory, Magdeburg, Germany, antonrlord@gmail.com