Measuring Neurovascular Coupling by Combining Electroencephalogram and Functional Transcranial Doppler: A Detailed Method
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1
University of South Australia, Cognitive Neuroscience Laboratory, School of Psychology, Social Work and Social Policy, Australia
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2
Macquarie University, ARC Centre of Excellence in Cognition and its Disorders, Department of Cognitive Science, Australia
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3
Flinders University, Brain and Cognition Laboratory, School of Psychology, Australia
Neuronal function and cerebrovascular supply are usually assessed in isolation however their relationship to each other is critical for brain function. Methods that do exist are typically expensive and unsuitable for populations where the technique would be most valuable, such as the very young and very old. Two groups have previously investigated the relationship between neural function and cerebrovascular supply by pairing electroencephalogram (EEG) and functional transcranial doppler (fTCD). EEG measures neural function via the recording of electrical activity at the scalp, while fTCD uses ultrasound to record blood flow velocity in major cerebral arteries. We furthered previously published methods by improving the data recordings between equipment, data processing methods and the incorporation of active as well as passive visual cognitive tasks. Visual evoked potentials were recorded from the occipital lobe and cerebral blood flow velocity was recorded from the posterior cerebral artery using fTCD while participants completed a passive checkerboard task, along with visual half-field tasks identifying either, tools or symmetrical shapes.
We will discuss the design of tasks, particularly given known differences in neural and hemodynamic responses to cognitive operations. Further, we will show how blood flow velocity and event-related potential (ERP; calculated from averaging EEG data) data are correlated and how the degree of correlation changes relative to ERP component and the segment of hemodynamic response (e.g. gain). This combined EEG-fTCD technique - which is non-invasive, not costly and suitable for most populations - stands to make valuable contributions to the understanding of neurovascular coupling in health and disease.
Keywords:
ERP,
Electroencephalogram,
hemodynamic response,
fTCD,
visual half-field,
Cerebral blood flow velocity,
functional transcranial Doppler,
event related potential components
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Methods Development
Citation:
Kurylowicz
L,
Badcock
N,
Kohler
M,
Churches
O and
Keage
H
(2015). Measuring Neurovascular Coupling by Combining Electroencephalogram and Functional Transcranial Doppler: A Detailed Method.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00305
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Miss. Lisa Kurylowicz, University of South Australia, Cognitive Neuroscience Laboratory, School of Psychology, Social Work and Social Policy, Adelaide, Australia, lisa.kurylowicz@unisa.edu.au