Changes of single word-induced cerebral oxy-Hb using Japanese and English Shiritori　in schizophrenia :Comparison with healthy subjects.
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1
Kurume University, School of Medicine, Neuropsychiatry, Japan
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2
Kurume University, Cognitive and Molecular Research Institute of Brain Diseases, Japan
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3
Kurume University, Cognitive and Molecular Research Institute of Brain Diseases,, Japan
Using NIRS (near-infrared spectroscopy), changes in cerebral oxidized hemoglobin (oxy-Hb) were measured by a Japanese and English Shiritori task. Shiritori is a very popular word game in Japan, involving saying a word that begins with the last character of the preceding word. Two kinds of Shiritori task were used (standard and creative tasks). Subjects were 30 healthy paid volunteers (age: 31.98.2) and age matched 30 schizophrenic patients (age: 31.87.7Changes in oxy-Hb were recorded during tasks from 44 recording sites (left: 22 channels, and right: 22 channels) using a multichannel NIRS instrument (EGT4000; Hitachi, Tokyo). Single Japanese or English word was appeared front TV monitor. All subjects were asked to a single Shiritori as soon as the stimulus. The subjects' pronounced 'a i u e o for Japanese or a b c d e for English task as resting state, and performed Shiritori as a task. Averaged waveforms from the 20 trials were measured, and changes of oxy-Hb from the resting state were converted to numeric values every 100 ms. The approximated value of area changes after the stimulus during for 6 seconds was analyzed as data. The ethics committee of Kurume University approved the present study. Written informed consent was obtained from all subjects.
The changes of oxy-Hb were evaluated from three ROIs (religions of interest)as frontal pole, middle prefrontal and associated areas. Significant differences in the changes of oxy-Hb were noted between healthy subjects and patients both in Japanes and English standard and creative tasks from all ROIs. Changes in oxy-Hb on the left frontal pole area were significantly, positively correlated with positive symptoms. Japanes and English Shiritori tasks using NIRS are useful for evaluating psychophysiological indices.
Keywords:
Executive Function,
Schizophrenia,
Hemoglobin,
Near-infrared Spectoscopy,
Shiritori
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Shoji
Y and
Morita
K
(2015). Changes of single word-induced cerebral oxy-Hb using Japanese and English Shiritori　in schizophrenia :Comparison with healthy subjects..
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00322
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Dr. Yoshihisa Shoji, Kurume University, School of Medicine, Neuropsychiatry, Kurume, Japan, yshoji@med.kurume-u.ac.jp
Prof. Kiichiro Morita, Kurume University, School of Medicine, Neuropsychiatry, Kurume, Japan, Kiichiro@med.kurume-u.ac.jp