Double dissociation in the roles of the left and right prefrontal cortices in anticipatory regulation of action
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1
University of California, Berkeley, Psychology, United States
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2
Veterans Affairs Northern California Health Care System, United States
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3
University of California, Davis, United States
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4
University of New Mexico, Psychiatry, United States
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5
University of New Mexico, Neurology, United States
Recent actions can benefit or disrupt our current actions. The prefrontal cortex (PFC) is thought to play a major role in the anticipatory regulation of actions. The left PFC has been associated with overcoming interference from past events in the context of language production and working memory. Moreover, the dorsolateral PFC has been associated with the ability to maintain task-sets, and improve the performance of current actions based on previous experience. However, potential hemispheric asymmetries in anticipatory regulation of action have not yet been determined.
Patients with left (n=7) vs. right (n=6) PFC damage due to stroke and aged- and education-matched controls performed a picture naming and a verbal Simon task (participants had to say "right" or "left" depending on the color of the picture while ignoring its position). In both tasks, performance depended on the nature of the preceding trial. In the naming task, performance decreased if previous pictures were from the same vs. from different semantic categories (i.e., the semantic interference effect). In the Simon task, performance was better in compatible trials (i.e., response matching the position of the stimulus) following compatible (cC) vs. incompatible trials (iC), and vice-versa for incompatible trials (i.e. the Gratton effect).
Left PFC patients were selectively impaired in picture naming: they had an increased semantic interference effect compared to both right PFC patients and to aged-matched controls. Conversely, right PFC patients were selectively impaired in the Simon task compared to controls or left PFC patients: they showed no benefit on cC trials compared to iC trials. This provides evidence for a double dissociation between left and right PFC in the anticipatory regulation of action: left PFC is involved in overcoming interference from past events and right PFC facilitates repetitions of task-set in the absence of interference.
Keywords:
Prefrontal Cortex,
hemispheric differences,
Gratton effect,
proactive control,
Semantic interference effect
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Ries
S,
Greenhouse
I,
Dronkers
NF,
Haaland
KY and
Knight
RT
(2015). Double dissociation in the roles of the left and right prefrontal cortices in anticipatory regulation of action.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00397
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Dr. Stephanie Ries, University of California, Berkeley, Psychology, Berkeley, United States, sries@sdsu.edu