The human centromedian-parafascicular complex (CM/Pf) is involved in processing of behaviorally relevant auditory events
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1
Medical School Hanover, Germany
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2
University of Cologne, Germany
The centromedian-parafascicular complex (CM-Pf) of the thalamus was found to be sensitive to behaviorally significant sensory events and was suggested to play an essential role in the process of attentional orienting to external events. We here investigated its involvement in processing of task relevant auditory information by simultaneous cortical and subcortical recordings in patients with chronic neuropathic pain during an auditory three-class oddball paradigm. This task typically produces a P3 component to relevant stimuli and is known to reflect attentional processes requiring stimulus detection and discrimination.
Simultaneous intracranial local field potentials (LFPs) and scalp electroencephalography (EEG) were obtained in 5 patients (1 female) implanted with quadripolar electrodes in the CM-Pf for deep brain stimulation (DBS). Within 5 days after surgery, patients performed the oddball paradigm with externalized DBS electrodes. Subcortical and cortical event-related potentials (ERPs) were analyzed upon presentation of one frequent standard stimulus (900Hz; 72%) and two infrequent stimuli (600Hz and 1200Hz; 14%), either being a relevant or a distractor stimulus. Furthermore, on the basis of previous studies investigating saliency, we tested whether neural oscillations in the beta (15-30 Hz) frequency range were modulated as a function of stimulus relevance.
Analysis revealed high accuracy of 89.6% ± 5.7 SEM. Cortical recordings over parietal regions and subcortical recordings in the CM-Pf thereby showed largest P3 responses after presentation of rare relevant stimuli. Interestingly, peak latencies in the CM-Pf occurred prior to the cortical response. In addition, the time-frequency analysis of the CM-Pf revealed that neural oscillations in the beta frequency range were enhanced for relevant stimuli.
The CM-Pf seems to be involved in the mechanisms of selective attention and processing of behaviorally relevant sensory events based on simple auditory information.
Keywords:
intracranial ERPs,
scalp ERPs,
CM-Pf,
Attention,
P3
Conference:
SAN2016 Meeting, Corfu, Greece, 6 Oct - 9 Oct, 2016.
Presentation Type:
Poster Presentation in SAN2016 Conference
Topic:
Posters
Citation:
Beck
A,
Sandmann
P,
Schwabe
K,
Lütjens
G,
Abdallat
M,
Dengler
R and
Krauss
JK
(2016). The human centromedian-parafascicular complex (CM/Pf) is involved in processing of behaviorally relevant auditory events.
Conference Abstract:
SAN2016 Meeting.
doi: 10.3389/conf.fnhum.2016.220.00069
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Received:
29 Jul 2016;
Published Online:
01 Aug 2016.
*
Correspondence:
Ms. Anne-Kathrin Beck, Medical School Hanover, Hanover, Germany, Beck.Anne-Kathrin@mh-hannover.de