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Adaptation and validation of the Cantonese Sydney Language Battery for assessment of language deficits in patients with primary progressive aphasia in Hong Kong

Adrian Wong1, 2*, Sharon Savage3, 4, Connie Yan5, Lisa Au1, 2, 6, Joshua Tsoh5, Bonnie Y. Lam2, Anthea Y. Ng2, Yuen H. Yuen7, Daphne Law8, John Hodges9, 10 and Vincent C. Mok1, 2, 6
  • 1 Therese Pei Fong Chow Research Centre for Prevention of Dementia, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR China
  • 2 Department of Medicine and Therapeutics, Chinese University of Hong Kong, China
  • 3 University of Exeter, United Kingdom
  • 4 Department of Psychology, College of Life and Environmental Sciences, University of Exeter, United Kingdom
  • 5 Department of Psychiatry, The Chinese University of Hong Kong, China
  • 6 Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, China
  • 7 Department of Speech Therapy, Shatin Hospital, China
  • 8 Department of Occupational Therapy, Shatin Hospital, China
  • 9 Sydney Medical School, University of Sydney, Australia
  • 10 Brain and Mind Centre, University of Sydney, Australia

Background. Primary Progressive Aphasia (PPA) refers to a heterogeneous group of clinical syndromes characterized by progressive, selective and dominant speech deficits due to Frontotemporal Lobar Degeneration. The three variants of PPA includes Primary Non-Fluent Aphasia, Semantic Dementia and Logopenic Aphasia. Clinical differentiation of the PPA variants can be challenging. The Sydney Language Battery (SYDBAT) is a test of single-word processing for contains 4 tasks that assess Naming, Word Comprehension, Semantic Association and Repetition. It is shown to be valid and reliable as a psychometric tool to differentiate PPA variants. Objective. The objective of the study is to adapt a Cantonese version of the SYDBAT and to examine the criterion validity of the Cantonese SYDBAT in differentiating Cantonese-speaking patients diagnosed with different PPA variants. Methods. A Cantonese version of the SYDBAT was adapted from the English version via the following procedures: 1. Stimuli frequency selection by matching of frequency and difficulty levels of concrete nouns using data from existing English and Chinese corpora; 2. Adaptation of semantic association task using culturally relevant stimuli developed by consensus by a multidisciplinary expert panel; 3. Modification of Repetition Task using a non-word repetition task paradigm; 4. Independent translation and back translation of test instructions; and 5. Pilot testing in 30 healthy volunteers aged between 40 and 70. Items with less than 80% correct response rate were replaced. Results. Adaptation and pilot testing of the Cantonese version of the SYDBAT were completed. SD x 3, LPA x 1, PNFA x 2 were recruited as of April 2019. The Cantonese SYDBAT takes approximately 30 minutes to administer. Data collection is ongoing.

Acknowledgements

This project was supported by the Health and Medical Research Fund, the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region (Grant number 04153116). This abstract is affiliated with the symposium “Aphasia in neurodegenerative conditions.”

Keywords: primary progressive aphasia, diagnostic test, single word processing, language test design, language assessmenmt

Conference: Academy of Aphasia 57th Annual Meeting, Macau, Macao, SAR China, 27 Oct - 29 Oct, 2019.

Presentation Type: Poster presentation

Topic: Not eligible for student award

Citation: Wong A, Savage S, Yan C, Au L, Tsoh J, Lam BY, Ng AY, Yuen YH, Law D, Hodges J and Mok VC (2019). Adaptation and validation of the Cantonese Sydney Language Battery for assessment of language deficits in patients with primary progressive aphasia in Hong Kong. Front. Hum. Neurosci. Conference Abstract: Academy of Aphasia 57th Annual Meeting. doi: 10.3389/conf.fnhum.2019.01.00062

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Received: 06 May 2019; Published Online: 09 Oct 2019.

* Correspondence: PhD. Adrian Wong, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong, SAR China, adrianwong@cuhk.edu.hk