Adjusted Brain Measure (ABM): A simple, relative measure of brain status
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1
University of Minnesota, United States
Several measurements can be taken from a brain using various technologies, including magnetic resonance (MR), magnetoencephalography, electroencephalography, positron emission tomography, and others. In addition, several further measurements can be taken within these modalities. For example, within the MR technology, one can do structural imaging, diffusion weighted imaging, fMRI, spectroscopy, etc. Typically, the values for these measurements are reported as individual values (for a particular brain) or as summary statistics (e.g. mean and standard deviation) for a group of brains. Here we show how these diverse measurements can be adjusted to yield a single, composite measure (Adjusted Brain Measure, ABM) that can serve for ranking individual brains within a population. We calculate ABM by taking into account deviations from the norm (50th percentile) of individual measurements as well as the variability among these deviations. ABM has the following useful properties: (a) it is dimensionless and robust; (b) it can be calculated easily and quickly from small or very large sets of K measurements (2 ≤ K < ∞); and (c) it tends to zero for a set of measurements that are close to the norm in the study population and, hence, it can serve as a screening tool to identify brains deviating from the norm at a chosen threshold. The procedure by which ABM is obtained is fairly general and can be applied to other, very diverse fields where a distillation of multivariate data to a single index may be desired (e.g. cognitive assessments, general medical tests, environmental variables, socioeconomic applications, etc.).
Keywords:
Magnetic Resonance Imaging,
Magnetoencephalography,
relative scoring,
Neuroimaging,
adjusted brain measure
Conference:
Neuroinformatics 2014, Leiden, Netherlands, 25 Aug - 27 Aug, 2014.
Presentation Type:
Poster, not to be considered for oral presentation
Topic:
General neuroinformatics
Citation:
Georgopoulos
A and
Mahan
MY
(2014). Adjusted Brain Measure (ABM): A simple, relative measure of brain status.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2014.
doi: 10.3389/conf.fninf.2014.18.00079
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Received:
28 Apr 2014;
Published Online:
04 Jun 2014.
*
Correspondence:
Dr. Apostolos Georgopoulos, University of Minnesota, Minneapolis, United States, omega@umn.edu