252-site subdural LFP recordings in monkey reveal large-scale effects of selection attention.
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1
Radboud University, Netherlands
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2
University of Western Ontario, United States
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3
University of Freiburg, Germany
An essential mechanism during visual processing is selective attention. Selective attention lends a competitive bias to behaviorally relevant stimuli at the expense of irrelevant distracters. While information about distracters is filtered out, information about targets is routed through to be processed in depth [1]. This flexible routing of information might be subserved by a flexible pattern of synchronization among the involved brain areas [2]. In the awake monkey, several studies have demonstrated that attention enhances gamma-band synchronization inside V4 and few studies showed attentional effects on synchronization between pairs of areas. However, the pattern of synchronization among multiple areas simultaneously and their attentional modulation has not been revealed. To this aim, we trained a macaque monkey (Macaca Mulatta) to perform a change detection paradigm. While the monkey kept fixation, two stimuli (4 deg diameter sinusoidal gratings, drifting unidirectionally, 4 deg; of eccentricity) appeared. One of the gratings was cued to be the target stimulus. The monkey was rewarded if it reported unpredictable transient changes in the target’s orientation. When reliable performance was achieved, the monkey was subdurally implanted with a flexible micromachined 252-channel ECoG (electrocorticogram) array, over large parts of the left hemisphere [3]. We obtained chronic recordings spanning from area V1, through V4, parietal and central regions up to FEF, during task performance. We quantified local and interareal synchronization during attention by obtaining frequency-resolved LFP power and coherence. We found attentional modulation of rhythmic synchronization across multiple areas. Locally, attention caused an increase in gamma power in areas V1 and V4, and a decrease in beta power over dorsal parietal and FEF electrodes. FEF was involved in two synchronization networks: 1.) a low-gamma (35 Hz) synchronization with dorsal premotor cortex that was reduced by attention, and 2.) a beta1 (18 Hz) synchronization with dorsal parietal cortex that was strongly enhanced by attention. Similarly, area V4 was involved in two synchronization networks: 1.) a beta1 (18 Hz) synchronization with dorsal parietal cortex that was not affected by attention, and 2.) a gamma (6090 Hz) synchronization with V1 and V2 that was strongly enhanced by attention. Furthermore, we found a strong attentional enhancement of beta-1 synchronization between FEF and area V1. These results further advance the notion that selective attention modulates interareal interactions by modulating interareal synchronization.
Acknowledgments: This research was supported by the European Community’s Seventh Framework Programme (FP7/2007-2013), Grant Agreement "BrainSynch" HEALTH-F2-2008-200728 (P.F.), The Volkswagen Foundation Grant I/79876 (P.F.), and the European Science Foundation European Young Investigator Award Program (P.F.).
References
1. Reynolds JH, Chelazzi L (2004) Attentional modulation of visual processing. Annu Rev Neurosci 27: 611-647.
2. Womelsdorf T, Fries P (2007) The role of neuronal synchronization in selective attention. Curr Opin Neurol 17: 154-160.
3. Rubehn B, Bosman CA, Oostenveld R, Fries P, Stieglitz T (2009) A MEMS-based flexible multichannel ECoG-electrode array. J Neural Eng 6: 036003.
Conference:
Computational and Systems Neuroscience 2010, Salt Lake City, UT, United States, 25 Feb - 2 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Poster session III
Citation:
Bosman
CA,
Womelsdorf
T,
Oostenveld
R,
Rubehn
B,
De Weerd
P,
Stieglitz
T and
Fries
P
(2010). 252-site subdural LFP recordings in monkey reveal large-scale effects of selection attention..
Front. Neurosci.
Conference Abstract:
Computational and Systems Neuroscience 2010.
doi: 10.3389/conf.fnins.2010.03.00124
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Received:
01 Mar 2010;
Published Online:
01 Mar 2010.
*
Correspondence:
Conrado A Bosman, Radboud University, Nijmegen, Netherlands, c.bosman@donders.ru.nl