Arc expression and neuroplasticity in primary auditory cortex during initial learning are inversely related to neural activity
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1
Van der Veer Institute for Parkinson's and Brain Research, Brain and Behavior Discovery Institute, United States
Models of learning--dependent sensory cortex plasticity require local activity and reinforcement. An alternative proposes that neural activity involved in anticipation of a sensory stimulus, or the preparatory set, can direct plasticity, so that changes could occur in regions of sensory cortex lacking activity. To test the necessity of target--induced activity for initial sensory learning, we trained rats to detect a Low Frequency sound. After learning, \textit{Arc} expression and physiologically--measured neuroplasticity were strong in a High Frequency auditory cortex region that lacked target--induced activity in control animals. After 14 sessions, \textit{Arc} and neuroplasticity were aligned with target--induced activity. The temporal and topographic correspondence between \textit{Arc} and neuroplasticity suggests \textit{Arc} may be intrinsic to the neuroplasticity underlying perceptual learning. Furthermore, not all neuroplasticity could be explained by activity--dependent models, but can be explained if the neural activity involved in the preparatory set directs plasticity.
Conference:
2010 South East Nerve Net (SENN) and Georgia/South Carolina Neuroscience Consortium (GASCNC) conferences, Atlanta , United States, 5 Mar - 7 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Posters
Citation:
Carpenter-Hyland
EP,
Plummer
TK,
Vazdarjanova
A and
Blake
DT
(2010). Arc expression and neuroplasticity in primary auditory cortex during initial learning are inversely related to neural activity.
Front. Neurosci.
Conference Abstract:
2010 South East Nerve Net (SENN) and Georgia/South Carolina Neuroscience Consortium (GASCNC) conferences.
doi: 10.3389/conf.fnins.2010.04.00029
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Received:
16 Mar 2010;
Published Online:
16 Mar 2010.
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Correspondence:
Ezekiel P Carpenter-Hyland, Van der Veer Institute for Parkinson's and Brain Research, Brain and Behavior Discovery Institute, Christchurch, United States, echyland@mcg.edu