The sympathetic triad – sympathetic regulation and parasympathetic modulation of the fetal heart rate
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1
Friedrich Schiller University Jena, University Hospital, Dept. of Obstetrics, Germany
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2
Technical University Ilmenau, Germany
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3
Friedrich Schiller University Jena, University Hospital, Biomagnetic Center, Germany
The fetal heart rate is characterized by developmental changes with gestational age (GA) and, towards term, the formation of distinctive patterns indicating variant states of fetal activity. It is generally believed that both sympathetic tone increases with increasing activity and vagal influence matures with GA. Aim of the presented study was to evaluate different parameters of fetal beat-to-beat heart rate variability (fHRV) in terms of their reflecting the effects of the two branches of the autonomic nervous system. 103 healthy fetuses were studied once between 24-42 weeks GA by fetal magneticardiography recording a short time series of 5 min. Fetal QRS complexes were determined after subtraction of maternal artifacts. The time series was then used to reconstruct and pre-classify the fetal heart rate patterns (fHRP; <32 weeks GA: fHRP I; II, >32 weeks GA: fHRP I, II, III). The following fHRV parameters wer calculated: mean heart rate (mHR), SDNN, RMSSD, the SDNN/RMSSD ratio and the mean permutation entropy (PE_Mean). Fetuses in higher levels of activity reveal significantly higher SDNN/RMSSD ratio (fHRP III>III). mHR is significantly increased during fHRP III >32 weeks GA. The ratio SDNN/RMSSD reflects increasing vagal influence with GA when quiet fHRP are considered. The triad of mHR, SDNN/RMSSD ratio and PE_mean constitute a reasonable surrogate to estimate the current sympatho-vagal balance in the human fetus.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
Fetal and neonatal biomagnetism
Citation:
Schneider
U,
Fiedler
A,
Jaekel
S,
Haueisen
J,
Schleussner
E and
Hoyer
D
(2010). The sympathetic triad – sympathetic regulation and parasympathetic modulation of the fetal heart rate.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00125
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Received:
24 Mar 2010;
Published Online:
24 Mar 2010.
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Correspondence:
Uwe Schneider, Friedrich Schiller University Jena, University Hospital, Dept. of Obstetrics, Jena, Germany, uwe.schneider@med.uni-jena.de