Oxidative stress and brain glutamate-mediated excitability in depressed patients
-
1
ISTC-CNR, Italy
-
2
Isola Tiberina, AFaR, Fatebenefratelli hospital, Italy
-
3
G. D Annunzio University, Department of Clinical Sciences and Bioimaging , Italy
-
4
Campus Biomedico University, Department of Neurology, Italy
-
5
Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA, Italy
The pathophysiology of several neurodegenerative and neuropsychiatric diseases characterized by alterations of the cortical excitability has been recently linked to oxidative stress phenomena. In the present study, we investigated the relationship between circulating markers of oxidative stress and excitability of the primary sensory areas (S1) of depressed patients. Specifically, glutamate-mediated S1 excitability was marked by the amount of synchronously activated neurons firstly recruited (M20) by contra-lateral median nerve stimulation at wrist. Depressives showed higher levels of total and free copper than controls and lower levels of transferrin. They also showed lower left S1 excitability, inversely proportional to transferrin levels. Controls' excitability appeared instead inversely proportional to total and free copper levels, a relationship absent in depressives. Free copper levels resulted also inversely associated with the patients' clinical status. Our results indicate that oxidative stress affects neuronal excitability in depression. Depressives show decreased glutammatergic excitability and transferrin seems to act to counterbalance such a reduction. Copper, particularly in its ‘free’ form, appears to play a widespread metabolic role affecting the overall cognitive function.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
MEG: Clinical applications
Citation:
Salustri
C,
Squitti
R,
Zappasodi
F,
Tomasevic
L,
Ventriglia
M,
Bevacqua
G,
Fontana
M,
Rossini
PM and
Teccho
F
(2010). Oxidative stress and brain glutamate-mediated excitability in depressed patients.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00294
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
05 Apr 2010;
Published Online:
05 Apr 2010.
*
Correspondence:
Franca Teccho, ISTC-CNR, Rome, Italy, franca.tecchio@cnr.it