White Matter Abnormalities in Children with Temporal Lobe Epilepsy: A DTI and MEG Study
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1
University of Cincinnati, Cincinnati Children's Hospital Medical Center, United States
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2
Northeast University, United States
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3
Northeast University, Key Laboratory of Medical Image Computing of Ministry of Education, United States
Background and Purpose: The widespread propagation of synchronized neuronal firing in seizure disorders may affect cortical and subcortical brain regions. Diffusion tensor imaging (DTI) can noninvasively quantify white matter integrity. The purpose of this study was to investigate the abnormal changes of white matter in children with focal temporal lobe epilepsy (TLE) using DTI. Materials and Methods: Eight children with clinically diagnosed TLE and eight age- and sex-matched healthy controls were studied. DTI images were obtained with a 3T magnetic resonance imaging (MRI) scanner. The epileptic foci were localized with magnetoencephalography (MEG). Fractional anisotropy (FA), trace, 1-volume ratio (VR), parallel (λ||) and perpendicular (λâ”´) diffusivities in the genu and splenium of the corpus callosum, external capsule, anterior limbs of the internal capsule, and the posterior limbs of the internal capsule were calculated. The DTI parameters in the same brain regions between patients and controls were statistically compared. The DTI parameters of white matter between the hemisphere with seizure foci and the hemisphere without seizure foci were statistically compared. Results: In comparison to controls, patients with epilepsy had significantly lower FA and higher trace, 1-VR, λ|| and λâ”´ in white matter structures. There was no significant difference between the hemisphere with seizure foci and the hemisphere without seizure foci in TLE patients in terms of FA, trace, 1-VR, λ|| and λâ”´. Conclusion: The results of the present study indicate that children with TLE had significant abnormalities in the white matter in the hemisphere with seizure foci. Furthermore, these abnormal changes could be identified in the hemisphere without seizure foci. It seems that white matter abnormalities represent an underlying predisposing factor in the development of TLE.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
Epilepsy
Citation:
Meng
L,
Xiang
J,
Rose
D,
Zhao
H,
Zhao
D and
Yang
J
(2010). White Matter Abnormalities in Children with Temporal Lobe Epilepsy: A DTI and MEG Study.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00326
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Received:
06 Apr 2010;
Published Online:
06 Apr 2010.
*
Correspondence:
Lu Meng, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, United States, menglu1982@gmail.com