Multi-frequency microstructure of ictal high frequency oscillation (60-170Hz) in epilepsy patients: magnetoencephalography (MEG) study
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1
MEG-Center, Seoul National University Hospital, Republic of Korea
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2
Seoul National University College of Medicine, MEG Center, Department of Neurosurgery, Republic of Korea
The pathological excessive synchronous neuronal activity generates coherent high frequency oscillations (HFOs) before and during a seizure. Recent studies have reported the presence of HFOs as a good indicator for the epileptogenic zone. However, their internal dynamics has been poorly understood especially during a seizure. In this study, we present detailed internal dynamics of ictal HFOs (50-200Hz) from 12 epilepsy patients (30.2±13.6 years old, 18 seizures) using MEG (600Hz sampling rate). We found that ictal HFOs were composed of diverse high frequency bands that could be discriminated by their wave form. This finding suggests that a seizure could recruit several independent local synchronous networks and that MEG could discriminate the micro-structure of HFOs.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
Epilepsy
Citation:
Kwak
Y,
Che
H,
Kim
B,
Kim
E,
Kim
JS and
Chung
CK
(2010). Multi-frequency microstructure of ictal high frequency oscillation (60-170Hz) in epilepsy patients: magnetoencephalography (MEG) study.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00384
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Received:
08 Apr 2010;
Published Online:
08 Apr 2010.
*
Correspondence:
Yongho Kwak, MEG-Center, Seoul National University Hospital, Seoul, Republic of Korea, kwak@meg.re.kr