Influence of compression forces and superdisintegrants on tablets performance: comparison of biosusceptometry, water uptake and disintegration force
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1
UNESP, Univ Estadual Paulista, Brazil
Conventional tablets are the most popular solid dosage forms. Disintegration is an important parameter and is influenced by the excipients and compression forces. In experimental determination of tablet disintegration, the official apparatus does not describe satisfactorily the disintegration properties. Alternate Current Biosusceptometry (ACB) has become an alternative method for pharmaceutical research and demonstrated the capability to be used as a complementary tool for pharmaceutical products evaluation. The aim of this study was to quantify the tablet disintegration process by ACB and two apparatuses to measure water uptake (WU) and disintegration force (DF). ACB uses a set of induction coils to recording the magnetic flux variation obtained from the response of a magnetic material; the data is processed to obtain images which are segmented to quantify the disintegration. Apparatuses for WU and DF measurements consist in precision balance coupled to a force transducer to record the amount of water absorbed and the DF developed. Tablets (0.5g ferrite, 0.375g superdisintegrant and excipients) were obtained by direct compression (10-50 kN) on a single punch tablet machine. To investigate the relationship among the data, graphic profiles from ACB images, DF and WU were analyzed by employing Weibull distribution to evaluate the curve shape and the time needed to reach 63.2% of the maximal values. The results showed that the disintegration time is highly influenced by the compression force applied, which implies on a time delay on the evaluated parameters. All the data presented a high level of correlation among the techniques. This preliminary study demonstrated that ACB has enough sensibility to evaluate quality of solid dosage forms. Considering the improvements in instrumentation design, it is expected that ACB will become a powerful tool for pharmaceutical processes monitoring.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
Nanoparticles, Biosusceptometry and Effects of Magnetic Fields
Citation:
Américo
M,
Fonseca
P,
Evangelista
G,
Cora
L,
Oliveira
R,
Andreis
U and
Miranda
JR
(2010). Influence of compression forces and superdisintegrants on tablets performance: comparison of biosusceptometry, water uptake and disintegration force.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00396
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Received:
08 Apr 2010;
Published Online:
08 Apr 2010.
*
Correspondence:
Madileine Américo, UNESP, Univ Estadual Paulista, São Paulo, Brazil, madi_americo@yahoo.com