An Implantable Stimulation Device with Conduit Electrode for Functional Regeneration of Defected Nerve
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1
Seoul National University, School of Electrical Engineering and Computer Science, Republic of Korea
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2
Seoul National University, Department of Oral and Maxillofacial Surgery, School of Dentistry,, Republic of Korea
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3
Seoul National University, Dental Research Institute, Republic of Korea
A novel electrical stimulation device for regeneration of peripheral nerve is proposed. A polyimide based conduit with an integrated electrode was made by micro-fabrication and a collagen was coated on the surface of the conduit. A stimulator IC was designed that generates a biphasic current for electrical stimulation for the nerve. The stimulator IC was packaged using silicone rubber with a battery, and integrated with the electrode. The device was implanted in rats with 7mm nerve defect model for four weeks. After four weeks, its effect was evaluated on regenerating nerve by analyzing behavior test and measuring nerve action potential. The behavior test reflected both the sciatic functional index and the static sciatic index. The action potential was appeared in the experiment group, which threshold was 7.68 times higher in the experiment group compared to the normal one, while none was observed in the control group.
Keywords:
conduit electrode,
nerve defect model,
silicone packaging
Conference:
2nd International Conference on NeuroProsthetic Devices (ICNPD-2010), Beijing , China, 27 Feb - 28 Feb, 2010.
Presentation Type:
Oral Presentation
Topic:
Novel neuroprosthetic electrodes
Citation:
Lee
T,
Pan
H,
Kim
IS,
Kim
JK,
Hwang
SJ and
Kim
SJ
(2010). An Implantable Stimulation Device with Conduit Electrode for Functional Regeneration of Defected Nerve.
Front. Neurosci.
Conference Abstract:
2nd International Conference on NeuroProsthetic Devices (ICNPD-2010).
doi: 10.3389/conf.fnins.2010.09.00014
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Received:
13 Apr 2010;
Published Online:
13 Apr 2010.
*
Correspondence:
Tae Lee, Seoul National University, School of Electrical Engineering and Computer Science, Seoul, Republic of Korea, nemoABS01@frontiersin.org