Efferent connections of nucleus accumbens subregions of the domestic chick
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1
Semmelweis University, Department of Anatomy, Hungary
The mammalian nucleus accumbens (Ac) is responsible for motivation, emotionality and reward mechanisms, and has been envisaged as a limbic-motor interface, based on its input from the limbic forebrain and an output to the ventral pallidum (VP). In the domestic chick, Ac has three subdivisions. The rostral pole (AcR) is a homogenous region lying in the rostral part of basal telencephalon, while the caudal Ac can be subdivided into the core (AcC) and shell (AcS), the AcC corresponding to the ventromedial medial striatum laterodorsal to the bed nucleus of stria terminalis (BSTl), and the AcS lying ventrally and ventrolaterally to the AcC.
The efferents of AcC and AcS were studied using biotinylated dextrane amine (BDA) as anterograde tracer.
In the telencephalon, a massive projection from AcC and AcS was found in the VP, the pallido-septal transition zone and the nucleus of the diagonal band. We found many labelled fibers in BSTl with the injection site in the AcS, but much fewer in case of AcC injections.
In the diencephalon, the lateral hypothalamus and the lateral preoptic area receive strong projection from both shell and core. In the case of AcS injections, many BDA fibers were found in the ventromedial, anterior and posterior hypothalamic nuclei, retromammillary region and the nucleus dorsomedialis anterior thalami (DMA). In the DMA we found a few retrogradelly labelled cells, when the injection was placed in AcC.
In the brainstem, the bulk of accumbal (core and shell) fibers were found in the compact part of the substantia nigra and the medial parabrachial nucleus. Fibers arising from neurons in the AcS projects to the ventral tegmental area, the subcoeruleus nuclei, raphe nuclei and some regions of reticular formation. The AcC was found to project to the nucleus of the solitary tract and some nuclei of the vagal motor complex.
As indicated by the results, the dichotomy of core/shell projections in the chicken is most prominent in the lower brainstem.
Grant sponsor: OTKA K73219.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Sensory and motor systems
Citation:
Bálint
E and
Csillag
A
(2010). Efferent connections of nucleus accumbens subregions of the domestic chick.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00061
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Received:
21 Apr 2010;
Published Online:
21 Apr 2010.
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Correspondence:
Eszter Bálint, Semmelweis University, Department of Anatomy, Budapest, Hungary, pupalibera@yahoo.com