Effect of the SSRI escitalopram on sleep rebound following REM sleep deprivation
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1
Semmelweis University, Department of Pharmacodynamics, Hungary
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2
Semmelweis University and Hungarian Academy of Sciences, Group of Neurochemistry, Hungary
Background: Enhanced firing of serotonergic (5-HT) neurons, that increases extracellular serotonin concentration depresses the duration of all sleep stages, and promotes wakefulness. The frequent firing of the 5-HT neurons is the highest in active wake. Accordingly SSRI administration before sleep increases both rapid eye movement sleep (REM) and non-REM (NREM) latencies. Long-lasting and selective REM deprivation by the flower pot method causes rebound increase in REM sleep after sleep deprivation. Our aim was to study the effect of increased extracellular 5-HT concentration by the SSRI escitalopram during the rebound sleep after flower pot REM deprivation.
Methods: Male Wistar rats equipped with electroencephalographic (EEG) and electromyographic (EMG) electrodes, after the recovery period were placed onto flower pots (FP) or into home cages (HC) for 72 hours. After the deprivation 10 mg/kg escitalopram or vehicle (saline) was administered intraperitoneally. Thereafter frontoparietal EEG, EMG and motility were recorded in the first three hours of the rebound period starting at the beginning of the passive phase. The EEG power spectra were analyzed of the following sleep stages: active and passive wake, light and deep slow wave sleep (SWS-1, SWS-2) and REM. The results of HC, FP, escitalopram treated and vehicle groups were compared to each other.
Results: Our results show, that escitalopram in the HC animals decreased the duration of both REM and NREM stages. In FP animals, however, the effects of escitalopram were adverse on these two stages: REM duration was decreased, whilst SWS-2 was increased significantly in the first two hours of rebound sleep.
Conclusion: These results provide evidence for an unexpected regulatory effect of serotonin, namely promotion of non-REM especially SWS-2 sleep after long-term REM deprivation.
This work was supported by the 6th Framework Program of the EU, LSHM-CT-2004-503474.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Homeostatic and neuroendocrine systems
Citation:
Petschner
P,
Kostyalik
D,
Kátai
Z,
Kitka
T and
Bagdy
G
(2010). Effect of the SSRI escitalopram on sleep rebound following REM sleep deprivation.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00114
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Received:
23 Apr 2010;
Published Online:
23 Apr 2010.
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Correspondence:
Péter Petschner, Semmelweis University, Department of Pharmacodynamics, Budapest, Hungary, petschnerp@yahoo.com