Effects of the insecticide, esfenvalerate on ileum motility and basic neuronal synaptic functions in the rat
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1
Eötvös Loránd University, Department of Physiology and Neurobiology, Hungary
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2
Animal Breeding and Animal Hygiene Research Group of the Hungarian Academy of Sciences and Kaposvár University, Hungary
To evaluate the risk of using toxic chemicals as pesticides, it is important to have information about their effects on non-target species. Esfenvalerate is an insecticide of the pyrethrinoid group, it acts as an agonist of voltage-gated sodium channels. The most characteristic poisoning syndrome is the development of epileptic seizures. In case of accidental ingestion, the chemical is in contact with the digestion tract, so it is reasonable to examine its effects on the gut physiology also.
In the present experiments, esfenvalerate was administered to rats by gavage at a sublethal dose (20 mg/bwkg) and effects on ileum motility and electrophysiological activity were evaluated 1, 2 or 7 days after treatment.
Electrophysiological experiments were performed on cortical and hippocampal slices of rat brains by means of measuring extracellular field potentials. Changes of the excitability were examined, long-term plasticity was characterized with induction of LTP and short-term plasticity with paired-pulse stimulation tests. Esfenvalerate application slightly decreased the amplitude of the first component of evoked potentials in neocortex slices; this decrease was more expressed in hippocampal slices. The late component in contrary was increased, and in hippocampus, the appearance of a second population spike was more frequent. These changes persisted even at one week after treatment.
The tonicity and the contraction strength of isolated ileum were tested. The maximum contraction of each ileum segment was elicited with a high concentration KCl solution. The ileum segments were cumulatively treated with eight different concentrations of acetyl-choline (ACh). The tonicity and the amplitude decreased 7 days after treatment while the relative amplitude and tonicity increased 1 and 2 days after treatment. Esfenvalerate may change the membrane potential of the cells by changing the activation and inactivation of Na-channels. This overactivation may result in the death of cells.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Cellular neuroscience
Citation:
Szabó
E,
Varro
P,
Banczerowski-Pelyhe
I and
Világi
I
(2010). Effects of the insecticide, esfenvalerate on ileum motility and basic neuronal synaptic functions in the rat.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00128
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Received:
28 Apr 2010;
Published Online:
28 Apr 2010.
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Correspondence:
Eszter Szabó, Eötvös Loránd University, Department of Physiology and Neurobiology, Budapest, Hungary, eszterszabomail@gmail.com