Neurochemical organization of the olfactory system in the terrestrial snail, Helix pomatia: correlation between monoamine and cAMP levels and different odor and food stimulation
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1
Hungarian Academy of Science, Comparative Neurobiology Research Group, Department of Experimental Zoology, Balaton Limnological Research Institute, Hungary
Serotonin (5-HT) has been shown to play an important role in learning of invertebrates, including olfactory processing of terrestrial snails, and 5-HT and dopamine (DA) proved to be pivotal signaling molecules of feeding behavior in both vertebrates and invertebrates, including gastropods. Based on it, in the present study we analyzed the neurochemical background of aminergic regulation of odor and food information processing at both peripheral (tentacular ganglion) and central (procerebrum) level of the olfactory system of Helix pomatia. Changes of 5-HT and DA concentrations upon the effect of attractive odor and food stimuli, and the relationship of 5-HT and the cAMP system were determined. It was demonstrated that odor stimuli (lettuce or cucumber) evoked a moderate decrease of DA (18%) and 5-HT (12%) levels in the tentacular ganglion, meanwhile a strong reduction of DA (49%) and a much limited of 5-HT (22%) level could be detected in the procerebrum. When odor application was followed by a few bites on food a marked increase of the 5-HT level in both the tentacular ganglion (67-214%) and the procerebrum (84%) was measured, whereas the DA level increased only in the peripheral unit (25-93%). During continuous feeding 5-HT concentration increased by 40% in the procerebrum and decreased by 10% in satiated snails, whereas DA level decreasing by 20% during feeding returned to the control level in satiated animals. In the isolated procerebrum, incubation with 100 µM 5-HT or LSD resulted in a 300-500% increase of cAMP concentration, whereas in vivo a 24% enhancement occurred upon the effect of an attractive odor. Feeding also evoked a significant (37%) increase of the cAMP level. The results suggest that aminergic mechanisms are involved in a complex way in the regulation of olfactory (and related feeding) events, and that in this process the 5-HTergic signaling is positively coupled to the adenyl cyclase-cAMP system.
Support: OTKA grant, No. 78224.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Sensory and motor systems
Citation:
Hiripi
L,
Hernádi
L,
Ihász E
K,
Fekete
ZN and
Elekes
K
(2010). Neurochemical organization of the olfactory system in the terrestrial snail, Helix pomatia: correlation between monoamine and cAMP levels and different odor and food stimulation.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00168
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Received:
30 Apr 2010;
Published Online:
30 Apr 2010.
*
Correspondence:
Károly Elekes, Hungarian Academy of Science, Comparative Neurobiology Research Group, Department of Experimental Zoology, Balaton Limnological Research Institute, Tihany, Hungary, elekes@tres.blki.hu