Anticonvulsant effect of butanolic extract of Anacyclus pyrethrum roots in rat
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1
University Cadi Ayyad, Laboratory of Pharmacology, Neurobiology and Behavior,Faculty of science, Semlalia, Morocco
Popularly known as “pilletory”, Anacyclus pyrethrum root is used since Unani system of medicine for the treatment of epilepsy. In the present study the anticonvulsive effect of butanolic extract of the plant roots (BEPR) was evaluated on the model status epilepticus (SE).
SE was induced in wistar rat by an intraperitoneal injection of kainic acid (KA). In the present study we used 4 groups of rats: 1: animals injected with 8 mg / kg of KA to induce epileptic activity, 2: animals injected intraperitoneally with 600 mg / kg of BEPR, followed, 40 min later, by injection of 8 mg / kg KA, 3: the third group received only BEPR, and 4: the last group received only a vehicle.
The animals were observed during 6h following injections. Latency and seizure severity based on the number of wet dog shakes (WDS) were measured.
The results showed that the pre-treatment of rats by the BEPR decreases significantly the number of WDS, and increases considerably the latent period between the injection of the KA and the appearance of the crises. These behavioural results were confirmed by the immunohistochemical study at the level of the hippocampus, in which the Fos expression of the butanolic extract-treated animals largely reduced the number of labelled neurons with respect to the group, which received the KA alone.
This suggests that the BEPR causes an anticonvulsive effect on rats, however the mechanisms remain to be determined.
Conference:
2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010.
Presentation Type:
Poster Presentation
Topic:
Poster session 1: Neurodegenerative diseases
Citation:
Fakir
MB,
Bennis
M,
M'hamed
SB and
Sokar
Z
(2010). Anticonvulsant effect of butanolic extract of Anacyclus pyrethrum roots in rat.
Front. Neurosci.
Conference Abstract:
2nd NEUROMED Workshop.
doi: 10.3389/conf.fnins.2010.12.00008
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Received:
03 Jun 2010;
Published Online:
03 Jun 2010.
*
Correspondence:
S. B M'hamed, University Cadi Ayyad, Laboratory of Pharmacology, Neurobiology and Behavior,Faculty of science, Semlalia, Marrakesh, Morocco, bamhamed@ucam.ac.ma