Development and Plasticity of Neural Basis for Working Memory
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1
Karolinska Institute, Sweden
Working memory (WM) capacity develops throughout childhood, which is an important factor for academic performance. Deficits in WM are also associated with the attention deficits in ADHD. Maturation of fronto-parietal networks, as well as myelination of white matter tracts is important for this development. Preliminary data on how genes affect structural maturation and cognitive development during childhood will be presented.
Experience can also affect WM capacity. In particular, we have developed and tested a computerized method for training WM. These studies have shown that systematic training of WM during 5 weeks improves performance also of non-trained WM tasks, and tasks dependent on top-down attention. These effects have been shown to last at least 6 months. Furthermore, working memory training is associated with changes in fronto-parietal brain activity, as well as density of dopamine D1 receptors. This indicates training-induced plasticity in the neural systems underlying working memory both at the physiological and biochemical level.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Oral Presentation
Topic:
Symposium 9: NeuroRehabilitation
Citation:
Klingberg
T
(2010). Development and Plasticity of Neural Basis for Working Memory.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00035
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Received:
28 Jun 2010;
Published Online:
28 Jun 2010.
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Correspondence:
Torkel Klingberg, Karolinska Institute, Stockholm, Sweden, Torkel.Klingberg@ki.se