Quantitative Demonstration of Architectonically Comparable Areas in the Orbital and Ventromedial Frontal Cortex of the Human and the Macaque Brain
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1
McGill University, Montreal Neurological Institute, Canada
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2
University of British Columbia, Brain Research Centre, Canada
The orbital and ventromedial frontal cortical regions of the human and the macaque brains are composed of several spatially discrete areas which are defined histologically by their distinctive laminar architecture. Although considerable information has been obtained experimentally on the functions and connectivity of these areas in the macaque, the significance of these data to the human brain is obscured by ongoing uncertainty with regard to the location of comparable architectonic areas in the two species. To resolve this issue, we quantified the areal densities of cortical layers IV and Va in a large sample of the orbital and ventromedial frontal cortex in both species. We provide the first quantitative demonstration of architectonically comparable cortical areas in the human and the macaque brains. We also found that the quantified architectonic features arrange areas within the orbital and ventromedial frontal cortex along two dimensions: an anterior-to-posterior and a medial-to-lateral dimension. On the basis of these findings, and in light of known anatomical connections in the macaque, we suggest that this region of the human cortex contains at least two hierarchically structured networks of areas.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neuroanatomy
Citation:
Petrides
M and
Mackey
S
(2010). Quantitative Demonstration of Architectonically Comparable Areas in the Orbital and Ventromedial Frontal Cortex of the Human and the Macaque Brain.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00049
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Received:
28 Jun 2010;
Published Online:
28 Jun 2010.
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Correspondence:
Scott Mackey, McGill University, Montreal Neurological Institute, Montréal, Canada, mackeys@interchange.ubc.ca