Executive control and deep brain stimulation of the subthalamic nucleus: Inhibition and task switching in the Stroop test
-
1
Cleveland Clinic Foundation, Center for Neurological Restoration, United States
The subthalamic nucleus (STN) is a common surgical target in deep brain stimulation (DBS) treatment for the motor symptoms of Parkinson disease. Recent work [1] suggests that the right STN is part of a frontal-subcortical network involved in cognitive inhibition. If so, stimulation of the right STN would be expected to impact cognitive control. We examined performance on the Stroop test in 83 non-demented Parkinson patients. The Stroop test requires inhibition of prepotent responses and this version incorporates control and task switching conditions. Patients completed this measure during pre-surgical DBS evaluations (N=62) or six-month postoperative evaluations after left (9 patients) or bilateral (12 patients) STN DBS. Bilateral patients were younger and this was entered as a covariate into the analyses. The groups did not differ on other demographic or disease variables. Patients with bilateral STN electrodes were comparatively slower and/or error prone on inhibition, switching, and colour naming conditions. There was also a trend toward improved switching performance in the left group. The results are discussed in terms of a putative right-STN role in inhibition, and consequences of DBS for treatment of executive dysfunction in Parkinson disease are considered.
References
1. Aron et al. Journal of Neuroscience 2006, 27, 11860-11864
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neurologic
Citation:
Ahmed
A,
Cooper
SC,
Deogaonkar
M,
Floden
D,
Itin
I,
Kubu
CS and
Machado
A
(2010). Executive control and deep brain stimulation of the subthalamic nucleus: Inhibition and task switching in the Stroop test.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00143
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
01 Jul 2010;
Published Online:
01 Jul 2010.
*
Correspondence:
D. Floden, Cleveland Clinic Foundation, Center for Neurological Restoration, Cleveland, United States, flodend@ccf.org