Excitation and inhibition in cortical space
In the cerebral cortex the flow of information is continuously processed by ensembles of neurons arranged along two major functional cortical subdivisions namely layers and columns. Layers and columns span the tangential and radial dimension of the cortical sheet and are interconnected via axonal projections that ensure the coordination of neuronal activity along these two orthogonal dimensions. While this pattern of connectivity sets anatomical constraints on signal propagation across layer and columns, it alone does not determine the flow of neuronal activity through cortical circuits. Indeed, the relationship between excitation and inhibition in cortical space is just as crucial in directing the flow of information. We address the logic by which the specific spatial relationship between excitation and inhibition impacts the routing of information across layers and columns. We find a remarkably precise spatial overlap of the two opposing conductances across these two cortical dimensions. Despite this overlap, however, layer specific differences in the ratio between excitation inhibition channel information flow by generating lateral suppression and feed-forward facilitation. Thus, finely tuned spatial match between excitation and inhibition precisely orchestrates signal propagation across two main cortical subdivision, layers and columns.
Conference:
EMBO workshop: Gaba Signalling and Brain Networks , Amsterdam, Netherlands, 30 Jun - 2 Jul, 2010.
Presentation Type:
Oral Presentation
Topic:
Talks
Citation:
Adesnik
H and
Scanziani
M
(2010). Excitation and inhibition in cortical space.
Conference Abstract:
EMBO workshop: Gaba Signalling and Brain Networks .
doi: 10.3389/conf.fnins.2010.15.00040
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Received:
23 Jun 2010;
Published Online:
23 Jun 2010.
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Correspondence:
Massimo Scanziani, UCSD, San Diego, United States, massimo@ucsd.edu