Preferential connections of area 1 fingertip representation in primary somatosensory cortex of squirrel monkey
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1
Hungarian Academy of Sciences - Péter Pázmány Catholic University - Semmelweis University, Neurobionics Research Group, Hungary
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2
Hungarian Academy of Science, Alfréd Rényi Institute of Mathemathics, Hungary
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3
Vanderbilt University, Department of Psychology, United States
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4
Vanderbilt University, Departments of Radiology and Radiological Science, Psychology, and Institute of Imaging Science, United States
Areas 3b and 1 of the primary somatosensory cortex (SI) play fundamental roles in tactile perception. Although both areas exhibit similar functional organizations, it is thought that area 1 represents a higher processing stage than area 3b. The aim of our study was to explore the neural connectivity responsible for the integrative function of area 1. We combined functional mapping with neuronal tract tracing and investigated the input and output preference of distal finger pad representations of area 1 in the squirrel monkey, which have large cortical magnification factors for the tactile inputs from the glabrous skin. Quantitative density maps computed to define the preferential distribution of retrograde labeling indicated that the strongest input was restricted to the surrounding injected finger pad representation of area 1. Labeled intrinsic connections were reciprocally distributed between neighboring finger representation regions, supporting their close functional interactions in area 1 during touch. Long-range reciprocal connections with area 3b were formed with the homologous fingertip representation. Results suggest a role for area 1 in the coordination of information from area 3b from the different finger pads, where the lateral intrinsic connectivity could be responsible for the large multifinger receptive fields and overlapping functional maps found in area 1.
Acknowledgements
Supported by FIRCA NS059061, OTKA NN79366 and NIH NS044375.
Keywords:
Sensory and motor activity,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Sensory and motor activity
Citation:
Ashaber
M,
Pálfi
E,
Palmer
C,
Friedman
R,
Chen
L,
Roe
A and
Négyessy
L
(2011). Preferential connections of area 1 fingertip representation in primary somatosensory cortex of squirrel monkey.
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00083
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Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. M. Ashaber, Hungarian Academy of Sciences - Péter Pázmány Catholic University - Semmelweis University, Neurobionics Research Group, Budapest, Hungary, ashaberm@gmail.com