The effect of Antalarmin on cocaine-induced locomotion in mice
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1
University of Szeged, Department of Pathophysiology, Hungary
Introduction: In our study we investigated the role of CRF1 receptor (R) transmission in the acute and chronic cocaine-evoked locomotor behavior in mice. Methods: The behavioral experiments consisted of monitoring the horizontal (ambulance distance) and vertical (rearing) locomotion in a computerized open-field box for 30 min. The activity was taken to indicate anxiety-related behavior. To assess the contribution of CRF1R mediation in cocaine-evoked locomotion, pretreatment with Antalarmin (ANT), a CRF1R antagonist (0.1µg/2µl) was given i.c.v. 30 min before cocaine (25mg/kg) injection. Furthermore we tried to elucidate the effect of ANT on behavioral sensitisation to cocaine in a 5-day chronic setting. After daily injections of cocaine we assessed the effect of a single dose of ANT on 24-hour abstinence. Results: ANT had no significant effect on the horizontal and vertical locomotion induced by the single i.p. injection of cocaine, however, ANT increased the time spent in the center of the open-field box. In our chronic experiments, ANT caused a marked decrease in the development of behavioral sensitisation to cocaine. In the 24-hour withdrawal the single administration of ANT significantly reduced the horizontal activity of the mice. Conclusion: These data suggest a role of CRF1R mediation in chronic locomotor responses to cocaine.
Acknowledgements
This work was supported by ETT-08/2009 Grant and TÁMOP 4.2.1B.
Keywords:
Behaviour and cognition,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Behaviour and cognition
Citation:
Babits
A,
Csabafi
K,
Lipták
N,
Szakács
J and
Szabó
G
(2011). The effect of Antalarmin on cocaine-induced locomotion in mice.
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00085
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Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. A. Babits, University of Szeged, Department of Pathophysiology, Szeged, Hungary, anikobabits@gmail.com