The endocrine, behavioral and autonomic actions of neuropeptide SF
-
1
University of Szeged, Department of Pathophysiology, Hungary
Neuropeptide SF (NPSF) is a mammalian amidated neuropeptide, which is highly concentrated in the hypothalamus. Concerning its physiological function, to date, only its role in pain modulation and appetite were investigated, thus the present experiments focused on measuring the effect of NPSF on the hypothalamus-pituitary-adrenal (HPA) axis, behavior and autonomic function. The peptide was administered in different doses (0.25, 0.5, 1, 2, 5 μg) intracerebroventricularly to adult male rats, the behavior of which were then observed by means of telemetry, open field (OF) and elevated plus maze (EPM) tests. Plasma concentrations of ACTH and corticosterone were measured to determine NPSF’s influence on the HPA system. Effect on core temperature was also measured via telemetry. To establish the mediation of the HPA response, animals were pretreated with the corticotrophin-releasing factor (CRF) receptor antagonist α-helical CRF(9-41) (1 μg). Our results showed that NPSF triggered both ACTH and corticosterone secretion, however α-helical CRF(9-41) failed to inhibit these actions of NPSF. Spontaneous locomotor activity and the core temperature were elevated, however, the exploratory and stereotyped behavior in the OF experiment and the EPM test was not altered significantly by NPSF. These results demonstrate, that NPSF stimulates the HPA axis, although CRH mediation alone may not be responsible for its action. It would seem that NPSF has a hyperthermic effect and also induces locomotor activity.
Keywords:
Neuroendocrinology,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Neuroendocrinology
Citation:
Csabafi
K,
Jászberényi
M,
Bagosi
Z,
Babits
A,
Szakács
J and
Telegdy
G
(2011). The endocrine, behavioral and autonomic actions of neuropeptide SF.
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00104
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. K. Csabafi, University of Szeged, Department of Pathophysiology, Szeged, Hungary, zuley@mac.com