Noninvasive connectivity analysis: a novel methodology for functional cortical mapping
-
1
National Institute of Neuroscience, Hungary
-
2
Hungarian Academy of Sciences, Institute for Psychology, Hungary
-
3
Nortshore-LIJ HS, Dept. of Neurosurgery, United States
-
4
Pázmány Péter Catholic University, Faculty of Information Technology, Hungary
The current gold standard for localizing language and motor networks in humans is electrical stimulation mapping. However, alternative non-invasive methods are being evaluated including task related fMRI, resting state functional connectivity (RSFC) analysis of the BOLD signal and cortical evoked potentials (CEP). We sought to compare these methods in patients undergoing intracranial monitoring for intractable epilepsy. fMRI was recorded at rest and while performing language tasks in a 3T scanner in three patients with medically intractable epilepsy prior to implantation of subdural electrodes. Extra-operative functional electrical stimulation mapping (ESM) and single pulse stimulation for the analysis of CEP was performed using subdural implanted electrodes. Electrode coordinates were localized in MRI space in order to perform correlations between methods. RSFC analysis tended to be more sensitive in detecting ESM defined language areas than task-based fMRI. Similar networks were revealed using language-positive ESM electrodes as stimulation site for CEP and as a seed for RSFC analysis. However, they only partially overlaid with functional electrodes identified with ESM. RSFC analysis is a promising tool to localize functional language areas. The combined application of RSFC, task-based fMRI, and CEP in addition to high frequency stimulation mapping might increase the sensitivity of delineating crucial language areas.
Keywords:
methods,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Methods
Citation:
Entz
L,
Bickel
S,
Keller
CJ,
Tóth
E,
Erőss
L and
Ulbert
I
(2011). Noninvasive connectivity analysis: a novel methodology for functional cortical mapping.
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00112
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. L. Entz, National Institute of Neuroscience, Budapest, Hungary, laszlo.entz@gmail.com