Greater insular involvement in the restrictive than in the bingeing/purging subtype of anorexia nervosa in a set-shifting task : An fMRI study
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1
Ghent University, Dep. of Psychiatry and Medical Psychology, Belgium
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2
Ghent University, Dep. of Experimental Psychology, Belgium
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3
Tilburg University, Dep. of Cognitive Neuropsychology, Netherlands
Set-shifting has been described as a cross-diagnostic feature of eating disorders. In the current study possible differences have been investigated in the neural correlates of set-shifting abilities between the restrictive and binging/purging subtypes of anorexia nervosa (AN-R, AN-BP). For this purpose, three groups of participants (16 with AN-R, 13 with AN-BP and 15 healthy control participants) performed a set-shifting task during functional magnetic resonance imaging. As in a typical set-shifting experiment, participants had to switch between two easy tasks (i.e. “Is the presented number odd/even” or “Is the presented number smaller/larger than 5”). The trials in which the task had been repeated (repeat trials) have been compared with trials in which the task had been switched (switch trials). On the level of task performance, no significant group differences could be established. When comparing switch specific brain activity across study groups, a stronger activation has been found in the right anterior insular cortex extending to the right inferior frontal gyrus in AN-R compared to AN-BP and HC. No significant differences could be established between the latter. We speculate that changing demands might induce a stronger emotional response in patients with AN-R. The results suggest that the both subtypes of AN might have different neurobiological correlates, and thus, might benefit from different treatment approaches.
Keywords:
Anorexia Nervosa,
fMRI,
cognitive control,
subtyping,
set-shifting
Conference:
11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015.
Presentation Type:
Oral or Poster presentation
Topic:
Neuroscience
Citation:
Van Autreve
S,
De Baene
W and
Vervaet
M
(2015). Greater insular involvement in the restrictive than in the bingeing/purging subtype of anorexia nervosa in a set-shifting task : An fMRI study.
Front. Neurosci.
Conference Abstract:
11th National Congress of the Belgian Society for Neuroscience.
doi: 10.3389/conf.fnins.2015.89.00046
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Received:
30 Apr 2015;
Published Online:
05 May 2015.
*
Correspondence:
Miss. Sara Van Autreve, Ghent University, Dep. of Psychiatry and Medical Psychology, Gent, 9000, Belgium, sara.vanautreve@ugent.be