Long-term potentiation varies along the dorso-ventral axis in the mouse hippocampus
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KU Leuven, Brain & Cognition, Faculty of Psychology and Educational Sciences, Belgium
The mammalian hippocampus has long been implied in both cognitive functioning (especially episodic memory) and emotional behaviors like anxiety and depression. Increasing evidence suggests that these activities depend on different regions along the hippocampus. Based on behavioral, anatomical and gene expression studies, the dorsal, intermediate and ventral segments may even need to be considered as functionally distinct structures (Fanselow and Dong, 2010; Kheirbek et al., 2013). Synaptic plasticity, widely believed to represent the cellular basis of learning and memory, has also been reported to vary along the dorso-ventral (or rostro-caudal) axis. For instance, it was shown that the same high-frequency induction protocol leads to a higher magnitude of long-term potentiation (LTP) in the CA1 region of dorsal hippocampal slices compared to ventral slices (Maggio and Segal, 2007). In the dentate gyrus, recordings in freely moving rats showed a larger LTP obtained in the intermediate than in the dorsal part (Kenney and Manahan-Vaughan, 2013). Here, we confirm these in vivo results by showing that the magnitude of dentate gyrus LTP and input/output relationships also significantly vary along the dorso-ventral axis in acute mouse brain slices. Altogether, the hippocampal structure could be viewed as having a gradient with discrete functional domains (Strange et al., 2014). To some extent, this functional organization is expected to be conserved in humans, which likely has clinical implications for many hippocampus-related diseases.
Acknowledgements
AS is supported by a doctoral grant from the Agency for Innovation by Science and Technology in Flanders (IWT).
References
Fanselow MS, Dong H-W (2010) Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65:7–19.
Kenney J, Manahan-Vaughan D (2013) NMDA receptor-dependent synaptic plasticity in dorsal and intermediate hippocampus exhibits distinct frequency-dependent profiles. Neuropharmacology 74:108–118.
Kheirbek M a, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton A a, Hen R (2013) Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron 77:955–968.
Strange BA, Witter MP, Lein ES, Moser EI (2014) Functional organization of the hippocampal longitudinal axis. Nat Rev Neurosci 15:655–669.
Keywords:
Hippocampus,
Dentate Gyrus,
Dorso-ventral axis,
synaptic plasticity,
Long-Term Potentiation
Conference:
11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015.
Presentation Type:
Poster presentation
Topic:
Neuroscience
Citation:
Schreurs
A and
Balschun
D
(2015). Long-term potentiation varies along the dorso-ventral axis in the mouse hippocampus.
Front. Neurosci.
Conference Abstract:
11th National Congress of the Belgian Society for Neuroscience.
doi: 10.3389/conf.fnins.2015.89.00075
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Received:
30 Apr 2015;
Published Online:
05 May 2015.
*
Correspondence:
Prof. Detlef Balschun, KU Leuven, Brain & Cognition, Faculty of Psychology and Educational Sciences, Leuven, Vlaams-Brabant, 3000, Belgium, detlef.balschun@ppw.kuleuven.be