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Graphene Oxide and reduced Graphene Oxide as novel nanostructured materials for neuronal growth

Antonina Monaco1*, Anastasiya Moskalyuk1, Jaroslaw Motylewski1, Farnoosh Vahidpour2, Andrew M. H. Ng3, Kian Ping Loh4, Milos Nesladek2, 5 and Michele Giugliano1, 6, 7*
  • 1 University of Antwerp, Theoretical Neurobiology and Neuroengineering Laboratory, Department of Biomedical Sciences, Belgium
  • 2 University of Hasselt, Institute for Materials Research, Material Physics Division, Belgium
  • 3 Institute of Materials Research and Engineering, Agency for Science, Technology and Research, Singapore
  • 4 National University of Singapore, Department of Chemistry, Singapore
  • 5 IMEC, IMOMEC associated laboratory, Belgium
  • 6 Brain Mind Institute, Swiss Federal Institute of Technology, Switzerland
  • 7 University of Sheffield, Dept. Computer Science, United Kingdom

Thanks to their unique optical, mechanical and electronic properties, Carbon-based nanomaterials are considered as the most interesting and promising materials for biological applications. Among them, Graphene (Novoselov et al., 2004;Wick et al., 2014) became, in few years, extremely interesting for Neuroscientists, who are investigating its use for drug delivery and gene therapy (Feng et al., 2011), biosensors (Dey and Raj, 2010), tissue scaffolding (Kalbacova et al., 2010) and for building electrodes for neuronal electrical stimulation (Heo et al., 2011). Here we explored the use of Graphene Oxide (GO) and reduced Graphene Oxide (rGO) as substrates for neuronal growth, investigating their biocompatibility and their contingent effects on electrophysiological properties of neurons in vitro at single-cell and network-level. Our results show that both GO and rGO allow the formation of active and fully developed neuronal networks and that they do not affect the electrical phenotype of individual neurons, being them suitable candidates for neuronal interfacing.

References

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Keywords: graphene oxide, Neuroenginnering, primary neuronal culture, Cellular electrophysiology., Cytotoxicity

Conference: 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015.

Presentation Type: Poster presentation

Topic: Neuroscience

Citation: Monaco A, Moskalyuk A, Motylewski J, Vahidpour F, M. H. Ng A, Loh K, Nesladek M and Giugliano M (2015). Graphene Oxide and reduced Graphene Oxide as novel nanostructured materials for neuronal growth. Front. Neurosci. Conference Abstract: 11th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2015.89.00082

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Received: 30 Apr 2015; Published Online: 05 May 2015.

* Correspondence:
Dr. Antonina Monaco, University of Antwerp, Theoretical Neurobiology and Neuroengineering Laboratory, Department of Biomedical Sciences, Wilrijk, Antwerp, 2610, Belgium, antonina.monaco@uantwerpen.be
Prof. Michele Giugliano, University of Antwerp, Theoretical Neurobiology and Neuroengineering Laboratory, Department of Biomedical Sciences, Wilrijk, Antwerp, 2610, Belgium, michele.giugliano@uantwerpen.be