FlyDriver: A Connectomic Approach to Find Specific Drivers of Target Neuron in the FlyCircuit
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1
National Tsing Hua University, Institute of Biotechnology, Taiwan
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2
National Tsing Hua University, Brain Research Center, Taiwan
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3
National Center for High-performance Computing, Taiwan
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4
Academia Sinica, Genomics Research Center, Taiwan
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5
University of California at San Diego, Kavli Institute for Brain and Mind, United States
We collected about 4000 driver expression images of Drosophila melanogaster, which included Gal4, LexA, flipase and spilt-Gal4 system for manipulating neuronal circuit function. All confocal microscopy images was archived into a database, named FlyDriver. FlyDriver was followed the same platform of FlyCircuit. Therefore, we can compare single neuron image with driver image. Here, we used image-matching algorithm on both neuron-driver image pairs and driver-driver image pairs between FlyCircuit and FlyDriver, which amount over the 100 million image pairs was been calculated. The overlap information of neuron-driver image pairs could help user to find a specific driver with a target neuron. In addition, user could also find similar driver with overlap information of driver-driver image pairs. We have illustrated the utility of these image-matching data for identifying the putative driver expressed target neuron and finding the specific driver from a set of neuron images. For some expression pattern that did not exist in one single driver, we could use the overlap information to predict expression patterns that comes from the intersection region from two driver images. As a result, FlyDriver provided a web interface that allows users to find the driver with different criterion. This will facilitate finding a specific driver to understanding the function of neuronal circuit.
Keywords:
neuron image,
driver image,
image databse,
driver database,
Image matching algorithm
Conference:
Neuroinformatics 2015, Cairns, Australia, 20 Aug - 22 Aug, 2015.
Presentation Type:
Poster, to be considered for oral presentation
Topic:
Computational neuroscience
Citation:
Wang
T,
Lin
Y,
Lin
H,
Chuang
C,
Chiang
M and
Chiang
A
(2015). FlyDriver: A Connectomic Approach to Find Specific Drivers of Target Neuron in the FlyCircuit.
Front. Neurosci.
Conference Abstract:
Neuroinformatics 2015.
doi: 10.3389/conf.fnins.2015.91.00011
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Received:
02 May 2015;
Published Online:
05 Aug 2015.
*
Correspondence:
Prof. Ann-Shyn Chiang, National Tsing Hua University, Institute of Biotechnology, Hsinchu city, 300, Taiwan, aschiang@life.nthu.edu.tw