Event Abstract

Caffeine links dopamine and serotonin release during passive heat loading

  • 1 Soonchunhyang University, Health Care, South Korea
  • 2 Soonchunhyang University, Physiolog, South Korea
  • 3 Konyang, Seo, South Korea

The aim of this study was to investigate the serum serotonin (5-HT), prolactin (PRL) and plasma dopamine (DA) levels in humans with and without caffeine ingestion during and after passive heat loading (half immersion in 42°C hot water). Eleven male volunteers participated in the randomized experiment (CON, n=15, 200 mL of tap water vs. CAFF, n=15, 3 mg•kg-1 and 200 mL tap water). After 60 min, passive heat loading was conducted for 30 min. Blood samples were collected and assessed for 5-HT, DA and PRL with and without caffeine during and after passive heat loading. 5-HT was significantly lower in the CAFF group compared to the CON group after passive heat loading for 30 min (Post) (p < 0.05) and also after 60 min of resting (p < 0.01). DA and PRL were significantly higher in the CAFF group than in the CON group at the Post time point (p < 0.001). In conclusion, 3 mg•kg-1 caffeine ingestion prior to passive heat loading can alter central serotonergic and dopaminergic activity, which may contribute to reduced central fatigue and subsequently, to reduced general fatigue. Prolactin responses during passive heat loading were also significantly related to caffeine ingestion in this study. However, the inhibitory effects of DA on PRL by caffeine remain to be elucidated.

Acknowledgements

of the authors have any conflicts of financial interest to declare.

References

Bae, J.S., Lee, J.B., Matsumoto, T., Othman, T., Min, Y.K., and Yang, H.M. (2006). Prolonged residence of temperate natives in the tropics produces a suppression of sweating. Pflugers. Arch. 453, 67-72.
Blomstrand, E. (2001). Amino acids and central fatigue, Amino Acids. 20, 25–34.
Chaouloff, F., Laude, D., Merino, D., Serrurrier, B., Guezennec, Y., and Elghozi, J.L. (1987). Amphetamine and alpha-methyl-p-tyrosine affect the exercise-induced imbalance between the availability of tryptophan and synthesis of serotonin in the brain of the rat. Neuropharmacology. 26, 1099-1106.
Davis, J.M., and Bailey, S.P. (1997). Possible mechanisms of central nervous system fatigue during exercise. Med. Sci. Sports. Exerc. 29, 45-57.
Davis, J.M., Zhao, Z., Stock, H.S., Mehl, K.A., Buggy, J., and Hand, G.A. (2003). Central nervous system effects of caffeine and adenosine on fatigue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284(2), R399-404.
Fredholm, B.B., Bättig, K., Holmén, J., Nehlig, A., and Zvartau, E.E. (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev. 51, 83-133.
Freeman, M.E., Kanyicska, B., Lerant, A., and Nagy, G. (2000). Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 80, 1523-1631.
Keltikangas-Järvinen, L., and Salo, J. (2009) Dopamine and serotonin systems modify environmental effects on human behavior: a review. Scand. J. Psychol. 50, 574-582.
Kim, T.W., and Lee, J.B. (2013). The effects of caffeine ingestion before passive heat loading on serum leptin levels in humans. Appl. Biochem. Biotechnol. 171, 1253-1261.
Kim, T.W., Shin, Y.O., Lee, J.B., Min, Y.K., and Yang, H.M. (2010). Effect of caffeine on the metabolic responses of lipolysis and activated sweat gland density in human during physical activity. Food. Sci. Biotechnol. 19, 1077-1081.
Kim, T.W., Shin, Y.O., Lee, J.B., Min, Y.K., and Yang, H.M. (2011). Caffeine increases body temperature and sweating sensitivity during physical loading. J. Med. Food. 14, 1448-1455.
Lee, J.B., and Kim, T.W. (2014a). Increased levels of FFA during passive heat loading after a 2-week repeated heat load in Koreans. Int. J. Biometeorol. In press.
Lee, J.B., and Kim, T.W. (2014b). Passive heat loading links lipolysis and regulation of fibroblast growth factor-21 in humans. J. Therm. Biol. 45, 163-167.
Lee, J.B., Kim, T.W., Min, Y.K., and Yang, H.M. (2013). Seasonal acclimatization to the hot summer over 60 days in the Republicof Korea suppresses sweating sensitivity during passive heating. J. Therm. Biol. 38, 294–299.
Lim, B.V., Jang, M.H., Shin, M.C., Kim, H.B., Kim, Y.J., Kim, Y.P., Chung, J.H., Kim, H., Shin, M.S., Kim, S.S., Kim, E.H., and Kim, C.J. (2001). Caffeine inhibits exercise-induced increase in tryptophan hydroxylase expression in dorsal and median raphe of Sprague-Dawley rats. Neurosci. Lett. 308, 25-28.
Low, D., Cable, T., Purvis, A., 2005. Exercise thermoregulation and hyperprolactinaemia. Ergonomics. 48(11-14), 1547-1557.
Lin, T.W., and Kuo, Y.M. (2013). Exercise benefits brain function: the monoamine connection. Brain. Sci. 3(1), 39-53.
Meeusen, R., Watson, P., Hasegawa, H., Roelands, B., and Piacentini, M.F. (2006). Central fatigue: the serotonin hypothesis and beyond. Sports. Med. 36, 881-909.
Newsholme, E.A., Blomstrand, E., and Ekblom, B. (1992). Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids. Br. Med. Bull. 48, 477-495.
Okada, M., Mizuno, K., and Kaneko, S. (1996). Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum. Neurosci. Lett. 212, 53-56.
Shin, Y.O., Lee, J.B., Min, Y.K., and Yang, H.M. (2013). Heat acclimation affects circulating levels of prostaglandin E2, COX-2 and orexin in humans. Neurosci. Lett. 542, 17-20.
Soares, D.D., Coimbra. C.C., and Marubayashi. U. (2007). Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area.Neurosci. Lett. 415, 274-278.
Solinas, M., Ferré, S., You, Z.B., Karcz-Kubicha, M., Popoli, P., and Goldberg, S.R. (2002). Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens. J. Neurosci. 22, 6321-6324.

Keywords: Caffeine, Dopamine, Passvie heat loading, Prolactin, Serotonin

Conference: Neuroinformatics 2015, Cairns, Australia, 20 Aug - 22 Aug, 2015.

Presentation Type: Poster, not to be considered for oral presentation

Topic: Clinical neuroscience

Citation: Kim T, Lee J, Seo H, Min Y and Yang H (2015). Caffeine links dopamine and serotonin release during passive heat loading. Front. Neurosci. Conference Abstract: Neuroinformatics 2015. doi: 10.3389/conf.fnins.2015.91.00040

Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.

The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.

Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.

For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.

Received: 01 Mar 2015; Published Online: 05 Aug 2015.

* Correspondence: Prof. Tae-Wook Kim, Soonchunhyang University, Health Care, Asan, 336-745, 336-745, South Korea, kimtw@sch.ac.kr

© 2007 - 2020 Frontiers Media S.A. All Rights Reserved