Transfer entropy, symbolic transfer entropy and transcript mutual information indicators reveal a leading role of infragranular layers during slow oscillations
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1
IDIBAPS, Systems Neuroscience, Spain
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2
Fundación Escuela Medicina Nuclear (FUESMEN) CNEA-UNC, Argentina
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3
Centro de Investigación Operativa (CIO), Universidad Miguel Hernández, Spain
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4
Institució Catalana de Recerca i Estudis Avançats (ICREA), Spain
The recurrent circuitry of the cerebral cortex generates an emergent pattern of activity that is organized into rhythmic periods of firing and silence referred to as slow oscillations (ca 1 Hz). Slow oscillations not only are dominant during slow wave sleep and deep anaesthesia, but also can be generated by the isolated cortical network in vitro, being a sort of default activity of the cortical network. The cortex is densely and reciprocally connected with subcortical structures and, as a result, the slow oscillations in situ are the result of an interplay between cortex and thalamus. Due to this reciprocal connectivity and interplay, the mechanism responsible for the initiation of waves in the corticothalamocortical loop during slow oscillations is still a matter of debate.
The prevalent view is that infragranular layers of the cortex, where the highest firing rates are found, are leading the periods of activity or Up states, from where activity rapidly spreads to all cortical layers and subcortical structures such as the thalamus. However, other authors support that the slow wave activity is an emergent property of corticothalamocortical networks defining the origin of this activity as a balance between cortical and thalamic contributions.
To determine the directionality of the information flow between different layers of the cortex and the connected thalamus during spontaneous activity we obtained multilayer local field potentials from the rat visual cortex and from its connected thalamus, the lateral geniculate nucleus, during deep anaesthesia. We analyzed directionality of information flow between thalamus, cortical infragranular layers (5 and 6) and supragranular layers (2/3) by means of three information theoretical indicators: transfer entropy, symbolic transfer entropy and transcript mutual information. These three indicators coincided in finding that infragranular layers lead the information flow during slow oscillations both towards supragranular layers and towards the thalamus.
Acknowledgements
This work was supported by Ministerio de Ciencia e Innovación (BFU2011-27094) and by the EU PF7 FET CORTICONIC contract 600806 to MVSV. BR was supported by a FPI fellowship.
Keywords:
Information directionality,
slow oscillations,
transfer entropy,
symbolic transfer entropy,
transcript mutual information
Conference:
B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop), Barcelona, Spain, 29 Apr - 30 Apr, 2015.
Presentation Type:
Poster Presentation
Topic:
SESSION 1: Cortical Function and Computations
Citation:
Tort-Colet
N,
Monetti
R,
Amigó Garcia
JM and
Sanchez-Vives
MV
(2015). Transfer entropy, symbolic transfer entropy and transcript mutual information indicators reveal a leading role of infragranular layers during slow oscillations.
Front. Syst. Neurosci.
Conference Abstract:
B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop).
doi: 10.3389/conf.fnsys.2015.06.00013
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Received:
20 Apr 2015;
Published Online:
06 May 2015.
*
Correspondence:
Ms. Núria Tort-Colet, IDIBAPS, Systems Neuroscience, Barcelona, Spain, nt0084@gmail.com