The effect of Thyroxine upon cardiac muscle metabolism and ionic fluxes in old Wistar rats
-
1
University of Medicine and Pharmacy”Carol Davila”, Romania
-
2
National Institute of gerontology and Geriatrics”Ana Aslan”, Romania
-
3
Victor babes Institute, Romania
Introduction. Our previous studies (Rom.J.Gerontology and Geriatrics 2,4, 1990) have pointed out that water-contractile proteins interactions can be modified as a function of excess or hormone defficiency.The aim of this study was to see the effect of Thyroxine administrated in excess upon cardiac muscle metabolism, ATP ase activity,on total SH groups content as well as upon 45CaCl2 transport in 24 month old rat heart .Another objective was to see the effect of hormone stress upon nuclear DNA integrity, by means of TACS apoptosis DNA Laddering kit Etd.Br.
Results. Our data have pointed out that thyroid hormones administrated in excess in Wistar rats have an influence on protein and nucleic acids metabolism as well as upon membrane permeability.There is an increase in ATP ase activity under the effect of Thyroxine treatment and an immediate consequence is the increase in ATP consumption.
Conclusion.Cardiac hypertophy is achieved by inhibiting the normal mechanism of apoptosis.
Keywords:
Thyroxine,
Metabolism,
cardiac muscle
Conference:
8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010.
Presentation Type:
Poster
Topic:
Xenobiotic toxicity
Citation:
Revnic
CR,
Ginghina
C,
Prada
G,
Prada
S,
Pena
C,
Revnic
F and
Botea
S
(2010). The effect of Thyroxine upon cardiac muscle metabolism and ionic fluxes in old Wistar rats.
Front. Pharmacol.
Conference Abstract:
8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010.
doi: 10.3389/conf.fphar.2010.60.00190
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
28 Oct 2010;
Published Online:
04 Nov 2010.
*
Correspondence:
Dr. Cristian R Revnic, University of Medicine and Pharmacy”Carol Davila”, Bucharest, Romania, kityrom@yahoo.com