Teratogenicity of antibacterial drugs
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1
University of Novi Sad, Faculty of medicine, Serbia
Introduction. Administration of antibacterials during pregnancy is very common The pharmacoepidemiological studies dealing with prescription of drugs in pregnancy are numerous. Results showed, that only exceptionally drugs that are used in pregnancy have been proven teratogenic. However, little is known about subtle effects of drugs on fetal development, particularly when dealing with old drugs. The aim of the study was to establish the possible correlation between use of antibacterial drugs in pregnancy and occurrence of congenital malformations.
Methods. The study was performed in Novi Sad district, Serbia and Montenegro and involved 6099 women who terminated the pregnancy for medical reasons, had delivered during the observed period or had a positive genetic history. Pregnant women filled questionnaires in Clinic of Gynecology and Obstetrics and in Genetic Counseling Department. Only the women who took antibiotics during pregnancy were included in final analysis. After delivery or abortion, newborn and fetuses were analysed in order to establish exsistance of minor or major malformations.
Results. Of the 6099 investigated pregnant women, 392 of them (6.4 %) used antibacterial drugs. The most frequently used antibacterials were from category B (75.8 %), while 14.5 % antibiotics belonged to category D and 1.0 % to category X. The most often used antibiotics were cephalexin (22.2 %), amoxicillin (20.7 %) and ampicillin (14.3 %). In 14 embryos exposed to effects of beta-lactams in utero malformations were detected.
Conclusions. The results of this study show the need to analyse further the possible teratogenic potential even with those antibacterials which are considered safe as the minor malformations can pass undetected. Because of that and because of frequent use of antibacterials during pregnacy, detailed examinations concerning their safety should be made.
Keywords:
antibiotics,
Pregnancy,
Abnormalities,
Drug-Induced,
Teratogens
Conference:
8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010.
Presentation Type:
Invited speaker
Topic:
Xenobiotic toxicity
Citation:
Sabo
A and
Eric
M
(2010). Teratogenicity of antibacterial drugs.
Front. Pharmacol.
Conference Abstract:
8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010.
doi: 10.3389/conf.fphar.2010.60.00192
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Received:
28 Oct 2010;
Published Online:
04 Nov 2010.
*
Correspondence:
Dr. Ana Sabo, University of Novi Sad, Faculty of medicine, Novi Sad, Serbia, saboads@stcable.rs