Event Abstract

Evaluation of the Anti-Oxidant and Anti-Glycemic Activity of Selected Traditional Medicinal Plants After In vitro Digestion

  • 1 University of Nottingham Malaysia Campus, Malaysia

Background Although there were numerous studies on the therapeutic potential of local traditional medicinal plant (TMP) in South East Asia, relatively few studies have evaluated their bio-accessibility. The changes in the phenolic content, anti-oxidant, and anti-glycemic activities of TMP following the digestion process is yet to be addressed. This study aimed to investigate the effect of in vitro digestion on the anti-oxidant and anti-glycemic activities of twelve selected local TMP. Methods The moisture content of each TMP was determined before subjected to in vitro oral, gastric and duodenal phases of digestion. The raw and digested TMPs were compared for their anti-oxidant and anti-glycemic activities with seven in vitro mechanism based assays, namely the ferric reducing anti-oxidant power, trolox equivalent anti-oxidant capacity, 2,2-diphenyl-1-picryl-hydrazyl radical scavenging activity, total phenolic and flavonoid content, anti-α glucosidase and anti-α amylase activity. Results Centella asiatica showed the highest total anti-oxidant activity (reducing power and radical scavenging), phenolic and flavonoid contents while Morus alba and Dioscorea polystachya possessed the highest anti-α glucosidase and anti-α amylase potential. In vitro digestion significantly (p<0.05) increased the total anti-oxidant activity of four TMPs. Similar trend was observed in the anti-glycemic activity of all TMPs. However, the phenolic and flavonoid contents were significantly (p<0.05) reduced in selected TMPs after the digestion except for Angelica sinensis, Ginkgo biloba and Lycium barbarum. The TMP phenolic content was positively correlated with the total anti-oxidant activity (r=0.840, p<0.001). Principle component analysis showed that 47.2% variation in the anti-oxidant and anti-glycemic activities of TMP was attributed to the digestion process while 37.3% was due to the different variety of TMP. Conclusion In summary, Centella asiatica has the overall highest anti-oxidant index among the twelve TMP. The digestion process could improve the anti-oxidant and anti-glycemic activities of selected TMP, especially Dioscorea polystachya, Ginkgo biloba and Lycium barbarum.

Keywords: antioxidant, anti-glycemic, in vitro digestion, Phenolic & flavonoid content, Traditional medicinal plants

Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.

Presentation Type: Oral Presentation

Topic: Miscellaneous

Citation: Ng Z and See A (2019). Evaluation of the Anti-Oxidant and Anti-Glycemic Activity of Selected Traditional Medicinal Plants After In vitro Digestion. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00008

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Received: 30 Sep 2018; Published Online: 17 Jan 2019.

* Correspondence: Dr. Zhi Xiang Ng, University of Nottingham Malaysia Campus, Semenyih, Malaysia, ngzx_86@yahoo.com

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