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The effect of zinc supplementation on the improvement of clinical symptoms and the quality of life of persistent moderate severe allergic rhinitis patients

Anna M. Dewi1*, Dian I. Setyorini1 and Suprihati -1
  • 1 Diponegoro University, Indonesia

Background The aim of Allergic Rhinitis (AR) therapy is to overcome the symptoms in the early and late phases allergic reactions. The ARIA 2008 guideline recommends intranasal corticosteroids and antihistamine for 2 to 4 weeks for persistent moderate severe AR patients. Zinc as an anti-inflammatory is expected to be an alternative for intranasal corticosteroid replacement therapy. The aims of this study is to determine the effect of zinc supplementation on the improvement of clinical symptoms and the quality of life of persistent moderate severe AR patients. Methods It was an interventional study with pretest and posttest design. Administration of 40mg/day zinc tablets in patients with persistent moderate severe AR treated with cetirizine (treatment group) was compared with cetirizine only (control group). Assessment was done by Total Symptom Score and Quality of Life Score questionnaires at the beginning of therapy and second week after therapy. Statistical tests used were t test, Wilcoxon, and Mann Whitney test. Results There were 34 persistent moderate severe AR patients. Administration of zinc 40 mg/day for two weeks showed a significant reduction of mean total symptom score (treatment group 2,65 ± 2,499 and control group 5,12 ± 2,956, p: 0,012) and mean quality of life score (treatment group 9,12 ± 11,230 and control group 24,24 ± 14,237, p: 0,002). Conclusion Zinc supplements is useful to improve clinical symptoms and quality of life for moderate severe persistent AR patients.

References

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Keywords: zinc supplementation, Moderate Severe Persistent, allergic rhinitis, quality of life score (QOLS), Total symptom score

Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.

Presentation Type: Oral Presentation

Topic: Inflammatory diseases

Citation: Dewi AM, Setyorini DI and - S (2019). The effect of zinc supplementation on the improvement of clinical symptoms and the quality of life of persistent moderate severe allergic rhinitis patients. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00084

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Received: 05 Nov 2018; Published Online: 17 Jan 2019.

* Correspondence: Dr. Anna M Dewi, Diponegoro University, Semarang, Indonesia, anna_drtht@fk.undip.ac.id