Enhanced Stability and Bioavailability Systems Composed of Curcumin as a Natural Anticancer Compound
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1
University of Science, Malaysia, Malaysia
Background
In recent decade, abundant improvements have been made in order to develop novel drug delivery system especially for phytoconstituents. Curcumin is a phytoconstituent with wide range of antimicrobial and anticancer activities. However its bioavailability in plasma is very low because of its limited intestinal uptake and fast metabolism. The aim of this review is to identify different types of delivery systems to improve curcumin oral bioavailability.
Methods
This article reviews different types of nanotechnology-based delivery systems such as liposomes, inclusions, micelle and emulsions to increase the bioavailability and pharmacological efficacy of curcumin. Such delivery systems can be made using thin film method, extrusion method, homogenizer and super-critical method, freeze-drying method and ultrasonic method.
Results
Different types of curcumin delivery systems in this review have been discussed. Cyclodextrins have increased solubility of curcumin 3200 times. Also they improved its stability in neutral solution up to 45 times better than unformulated curcumin. Cyclodextrins have been evaluated clinically on healthy volunteers revealed 39 times higher bioavailability in comparison with unformulated curcumin.
Conclusion
The review demonstrated that cyclodextrins among other types of delivery systems are promising nano-formulation loading curcumin in order to enhance its bioavailability and pharmacological efficacy.
Keywords:
Curcumin,
stability,
Liposome,
Administration,
Cancer
Conference:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.
Presentation Type:
Poster Presentation
Topic:
Miscellaneous
Citation:
Nazari
M,
Aldeeb
I and
Abdul Majid
A
(2019). Enhanced Stability and Bioavailability Systems Composed of Curcumin as a Natural Anticancer Compound.
Front. Pharmacol.
Conference Abstract:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”.
doi: 10.3389/conf.fphar.2018.63.00094
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Received:
24 Oct 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
Dr. Mansoureh Nazari, University of Science, Malaysia, George Town, Malaysia, nazarimansoure@gmail.com